老年医学与保健2024，Vol.30Issue(4)：1041-1048,8.
硝苯地平缓释片联合依那普利治疗老年冠心病合并高血压患者的临床分析
Clinical analysis of nifedipine sustained-release tablets combined with enalapril in the treatment of elderly patients with coro-nary heart disease and hypertension
摘要
Abstract
Objective To explore the effects of nifedipine sustained-release tablets combined with enalapril in the treat-ment of elderly patients with coronary heart disease complicated with hypertension and its influence on cardiac function and vas-cular endothelial function,and provide methods for the treatment of this disease.Methods 115 elderly patients with coronary heart disease and hypertension admitted to General Hospital of Western Theater Command from February 2020 to February 2023 were enrolled and divided into enalapril group(n=58)and combined group(n=57)by simple randomization method.Both groups received conventional treatment.In addition,the enalapril group was treated with enalapril,and the combined group was treated with nifedipine sustained-release tablets combined with enalapril.The clinical efficacy of the two groups were observed and compared.The changes in cardiac function index values[systolic blood pressure(SBP),diastolic blood pressure(DBP)],blood pressure variability index values[24-hour mean systolic blood pressure variability(24 h SBPV),24-hour mean diastolic blood pressure variability(24 h DBPV)],vascular endothelial function index values[nitric oxide(NO),plas-ma endothelin(ET),vascular endothelial growth factor(VEGF)levels],oxidative stress index values[malondialdehyde(MDA),superoxide dismutase(SOD),and advanced oxidation protein products(AOPP)levels]before and after treatment were compared between the two groups.The adverse reactions of the two groups were compared.Results The total clinical effective rate of the combined group was significantly higher than that of the enalapril group(94.74％vs 81.04％,P＜0.05).After treatment,the LVEF levels of both groups were higher than those of the same groups before treatment(P＜0.05),while the levels of LVEDD,LVESD,MAP and HR were lower than those of the same groups before treatment(P＜0.05),but the differences before and after treatment between the two groups were statistically significant(P＜0.05);the levels of SBP,DBP,24-hour SBPV,and 24-hour DBPV of both groups were lower than those of the same group before treatment(P＜0.05),and the above indicators of the combined group were significantly lower than those of the enalapril group(P＜0.05);the levels of NO of both groups were higher than those of the same group before treatment(P＜0.05),while the levels of ET and VEGF were lower than those of the same group before treatment(P＜0.05),but the differences before and after treatment in the levels of NO,ET,and VEGF between the two groups were statistically significant(P＜0.05);the levels of SOD of both groups were higher than those of the same group before treatment(P＜0.05),while the levels of MDA and AOPP were lower than those of the same group before treatment(P＜0.05),but the differences before and after treatment in the levels of SOD,MDA,and AOPP between the two groups were statistically significant(P＜0.05).There were no statistical differences in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combination of nifedipine sus-tained-release tablets and enalapril has a significant therapeutic effect on elderly patients with coronary heart disease and hyper-tension.It can effectively stabilize blood pressure,improve heart and endothelial function,alleviate oxidative stress response,and has certain clinical application value.关键词
老年/冠心病/高血压/硝苯地平缓释片/依那普利/心功能/血管内皮功能Key words
elderly/coronary heart disease/hypertension/nifedipine sustained-release tablets/enalapril/cardiac func-tion/vascular endothelial function引用本文复制引用
龚月,宋辉,赵爽,寇丹,范萍..硝苯地平缓释片联合依那普利治疗老年冠心病合并高血压患者的临床分析[J].老年医学与保健,2024,30(4):1041-1048,8.基金项目
四川省干部保健科研课题(川干研2021-1301) （川干研2021-1301）
