棉纺织技术2024，Vol.52Issue(9)：34-40,7.
单向导湿抗菌敷料的制备及性能研究
Preparation and property study of antibacterial dressings with unidirectional moisture transmissibility
摘要
Abstract
In order to obtain the wound dressings with unidirectional moisture transmissibility and antibacterial property,polylactic acid/nano-zinc oxide-PLA/chitosan(PLA/ZnO-PLA/CS)nanofiber membrane with double-layered structure and polylactic acid/nano-zinc polylactic acid/chitosan polyvinyl alcohol/hyaluronic acid(PLA/ZnO-PLA/CS-PVA/HyA)nanofiber membrane with tri-layered structure were successfully prepared by electrospinning technology.The micro-morphology,chemical group,ink diffusion,water absorption,hydrophilicity,antibacterial property and biosecurity of bi-layered and tri-layered dressings were tested and analyzed.The results showed that the fiber diameter of nanofibers were gradually decreased,pore diameter was gradually decreased and the porosity was gradually increased from PLA/ZnO inlayer,PLA/CS interlayer to PVA/HyA outer layer.The tri-layered nanofiber membrane with gradient structure had the best hydrophilicity for the antibacterial dressings.Antibacterial zone could be obviously formed in the PLA/ZnO inner layer with better antibacterial property.Cell proliferation would not be affected by the tri-layered gradient structural dressing ingredient and it was non cytotoxicity.PLA/CS layer and PVA/HyA layer formed a gradient drainage structure with excellent unidirectional moisture transmissibility,which could drain the wound effusion to the outer layer of the dressing.It is considered that tri-layered gradient nanofibrous membranes with 3 h spinning has excellent performances in moisture transmissibility and antibacterial property.It is out of cytotoxicity and suitable for the development of wound dressing related products.关键词
创伤敷料/梯度结构/单向导湿/抗菌性能/纳米纤维Key words
wound dressing/gradient structure/unidirectional moisture transmissibility/antibacterial property/nanofiber分类
轻工业引用本文复制引用
张赛,董硕,董东东,葛效成,陈振远,王蕊鑫,孙召彬,杨帆..单向导湿抗菌敷料的制备及性能研究[J].棉纺织技术,2024,52(9):34-40,7.基金项目
国家自然科学基金项目(22104010) （22104010）
山东省自然科学基金项目(ZR2021QB141) （ZR2021QB141）
