国际眼科杂志2024，Vol.24Issue(9)：1426-1431,6.DOI:10.3980/j.issn.1672-5123.2024.9.14
PI3K/AKT通路在糖尿病视网膜病变中的调控作用
Regulatory role of PI3K/AKT pathway in diabetic retinopathy
摘要
Abstract
·Diabetic retinopathy(DR)is one of the major complications of diabetes mellitus,characterized by neurodegeneration and microangiopathy.Currently,the treatment of DR is mainly focused on the management of late complications and has not achieved the desired clinical outcome.Evidence suggests that the PI3K/AKT pathway,as one of the important intracellular signaling pathways during the cell cycle,is involved in the whole process of DR pathogenesis.This article focuses on the structural composition,activation and blocking pathways,conduction pathways,regulatory mechanisms and biological functions of the PI3K/AKT signaling pathway to review its role in DR and to explore the potential of targeting the PI3K/AKT pathway for the treatment of DR.关键词
PI3K/AKT通路/糖尿病视网膜病变/神经退行性病变/微血管病变Key words
PI3K/AKT pathway/diabetic retinopathy/neurodegenerative disease/microangiopathy引用本文复制引用
李宝花,亢泽峰,侯昕玥,王健全,宋曼,李丹玉,刘梦雨,晏鑫..PI3K/AKT通路在糖尿病视网膜病变中的调控作用[J].国际眼科杂志,2024,24(9):1426-1431,6.基金项目
中医药传承与创新"百千万"人才工程(岐黄工程)岐黄学者{ No.国中医药人教发[2018]284号｝ （岐黄工程）
福建省第三批柔性引进医疗卫生高层次人才团队 （）
北京市石景山区亢泽峰名医传承工作室项目 Chinese Medicine Inheritance and Innovation"Millions Upon Millions"Talent Project(Qihuang Project)Qihuang Scholars[No.284 of the National Chinese Medicine Education Development(2018)] （Qihuang Project）
The Third Batch of Flexible Introduction of Medical and Health Care High-level Talent Team in Fujian Province （）
Beijing Kang Zefeng Famous Doctor Inheritance Workshop Project in Beijing Shijingshan District （）
