国际眼科杂志2024，Vol.24Issue(9)：1432-1437,6.DOI:10.3980/j.issn.1672-5123.2024.9.15
脂质代谢在新生血管性年龄相关性黄斑变性进展及治疗中的作用
Role of lipid metabolism in the progression and treatment of neovascular age-related macular degeneration
摘要
Abstract
·Neovascular age-related macular degeneration(nARMD)is a prevalent age-related retinal disease that significantly impairs vision.Numerous studies have shown that lipid metabolism disorders contribute to the progression of nARMD.The relationship is complex and involved factors such as fatty acids,cholesterol,variations in lipid metabolism genes,and other influencing factors.Lipid metabolism disorders lead to retinal vascular abnormalities and inflammatory responses by triggering oxidative stress and inhibiting autophagy.This,in turn,accelerates the formation of new blood vessels and causes damage to macular cells and tissues.In animal experiments,drugs designed for lipid metabolism disorders have shown that regulating lipid metabolism could be a potentially effective strategy for treating nARMD.This article reviews the role of lipid metabolism in the progression and treatment of neovascular age-related macular degeneration,aiming to offer new insights for nARMD treatment.关键词
脂质代谢/新生血管性年龄相关性黄斑变性/氧化应激/自噬/脂质代谢相关药物治疗Key words
lipid metabolism/neovascular age-related macular degeneration/oxidative stress/autophagy/lipid metabolism-related drug therapy引用本文复制引用
宋维晨,陈雯,池敬毅,祝文文..脂质代谢在新生血管性年龄相关性黄斑变性进展及治疗中的作用[J].国际眼科杂志,2024,24(9):1432-1437,6.基金项目
山东省自然科学基金面上项目(No.ZR2023MH069) （No.ZR2023MH069）
潍坊市卫生健康委科研项目(No.WFWSJK-2023-163) （No.WFWSJK-2023-163）
潍坊市青年医学人才托举工程资助 Natural Science Foundation of Shandong Province(No.ZR2023MH069) （No.ZR2023MH069）
Weifang Health Commission Scientific Research Project(No.WFWSJK-2023-163) （No.WFWSJK-2023-163）
Weifang Young Medical Talent Support Program Funding （）
