刘菂 1瞿洪平 1徐志红 2曹久妹 2郑岚 3白婷婷2
作者信息
- 1. 上海交通大学医学院附属瑞金医院 重症医学科,上海 200025
- 2. 上海交通大学医学院附属瑞金医院 老年病科,上海 200025
- 3. 上海交通大学医学院附属瑞金医院 中医科,上海 200025
- 折叠
摘要
Abstract
Objective To explore the effect of Shenfu injection on immune function in elderly patients with sepsis.Methods This study was a retrospective analysis.The elderly patients(n=126)with sepsis admitted to 4 hospitals including Shanghai Ruijin Hospital from January 2019 to December 2020 were divided into two groups according to whether Shenfu injection was used(61 cases in Shenfu group,65 cases in control group).Basic data,comorbidities,relevant test results(including inflammatory factors,humoral immune indicators,cellular immune indicators,etc.),disease severity score,mortality rate,etc.,were collected for statistical analysis.Results After seven days of Shenfu injection treatment,the indexes including the mean artery pressure(MAP),lactate(Lac),C-reactive protein(CRP),procalcitonin(PCT),prothrombin time(PT),activated partial thromboplastin time(APTT),interleukin-6(IL-6),IL-10,tumor necrosis factor-α(TNF-α),CD3 count,CD4 count,CD8 count,IgG,IgA and IgM of patients in 2 groups were significantly improved(all P<0.05).Compared with the control group,MAP(P=0.034),and the absolute count of CD3(P=0.002)and CD4(P=0.002)were significantly increased in the Shenfu treated group.Conclusions Shenfu injection combined with standard bundled regimen can improve the immune function and reduce inflammation in elderly patients with sepsis.关键词
老年/脓毒症/免疫功能/炎症因子Key words
Elderly/Sepsis/Immune function/Inflammatory factors分类
医药卫生
