内科理论与实践2024，Vol.19Issue(3)：167-173,7.DOI:10.16138/j.1673-6087.2024.03.03
牙周治疗改善非酒精性脂肪性肝病的探索性研究
An exploratory study of periodontal therapy to improve non-alcoholic fatty liver disease
摘要
Abstract
Objective To study the effect of Porphyromonas gingivalis(P.g)on non-alcoholic fatty liver disease(NAFLD)and the ameliorative effect of periodontal treatment on NAFLD.Methods Mice fed a high-fat diet for 4 weeks were randomly divided into two groups,and there were 8 mice in each group.Group A was blank control,and Group B was given suture ligation+smeared P.g.They were sacrificed after 4 weeks of intervention,and the changes in liver,inflammatory factors were tested.Eight NAFLD patients with periodontal disease were randomly divided into the subgingival scaling group and the control group(4 in each group),and the subgingival scaling group received the basic periodontal treatment.Changes in periodontal status,liver,and blood biochemistry before and after the intervention were tested in the 2 group patients.Results Compared with the control mouse group,the ligation and smear mouse group had increased liver weight,formation of lipid deposits,serum lipid,aspartate transaminase and ferritin levels,and the expression of serum inflammatory mediators was increased.Compared with the patients in the tooth brushing group,the subgingival scraping patient group showed a significantly decreased indexes such as P.g-IgG antibody titer,probing depth,as well as a downward trend in liver fat content,but the differences were not statistically significant(P>0.05).Conclusions P.g infection can accelerate the progression of NAFLD in mice with high-fat diet,and the periodontal treatment in patients showed a mitigating effect on periodontal infection-associated NAFLD.关键词
龈下刮治/牙周病/非酒精性脂肪性肝病/牙龈卟啉单胞菌Key words
Subgingival scaling/Periodontal disease/Non-alcoholic fatty liver disease/Porphyromonas gingivalis分类
医药卫生引用本文复制引用
段中华,马雪莹,吴玉琼,舒家恩,吴沛,郭斯敏,王宇华..牙周治疗改善非酒精性脂肪性肝病的探索性研究[J].内科理论与实践,2024,19(3):167-173,7.基金项目
国家口腔疾病临床医学研究中心上海交通大学医学院附属第九人民医院口腔医学临床研究攻关项目(NCRCO202332) （NCRCO202332）
口腔疾病研究国家重点实验室开放课题(SKLOD2022OF01) （SKLOD2022OF01）
