水产学报2024，Vol.48Issue(9)：1-21,21.DOI:10.11964/jfc.20240114344
鱼类肌肉生长研究进展
Advances of fish muscle growth
摘要
Abstract
Fish is a vital source of animal-based protein due to its abundant muscle content.The objective of fish aquaculture is to enhance muscle fibers hyperplasia and hypertrophy through optimal breeding conditions and technologies,thereby accelerating muscle growth and increasing the economic viability of industry.The fundamental processes of fish muscle growth involve hyperplasia and hypertrophy of muscle fibers,coupled with the ongoing fusion of muscle cells,culminating in the development of larger myotubes or thicker myofibers.Before the differentiation of myotubes into two distinct muscle fibers—white(fast)and red(slow)muscle tissues—the cells undergo gradual specilization,assembling and expressing muscle-specific proteins,including various myosin isoforms.This review summarizes the latest insights into fish muscle growth,encom-passing cell proliferation,migration,differentiation,cell-cell fusion and muscle fibers formation.It also identifies key regulatory factors(pax3,pax7,myf5,myod,myog and mrf4)and the GH-IGF signaling pathway that influence muscle development.The review elucidates the transition of mononucleated muscle cells into syncytial fibers dur-ing growth and development.Notably,two novel gene orthologs,mymk and mymx,are implicated in muscle cell fusion and are conserved across vertebrate.The determinants of fusion,such as cell adhesion molecules,fuso-gens,and actin cytoskeletal regulators,which facilitate the formation of finger-like projections,are crucial for muscle cell fusion.This review further explores potential aquatic genetic resources for breeding to enhance muscle growth and discusses dietary approaches to improve fish meat quality.By integrating these findings,we introduce a novel perspective on muscle growth enhancement through nutritional and genetic interventions.Collectively,this review offers a comprehensive overview of aquaculture traits development,focusing on rapid growth and enhanced muscle quality.关键词
鱼类肌肉生长/肌纤维增殖/肌纤维增粗/生肌调节因子/肌细胞融合/mymk/mymx/mstnKey words
fish muscle growth/muscle fiber hyperplasia/muscle fiber hypertrophy/myogenic regulatory factor/myoblast fusion/mymk/mymx/mstn分类
生物科学引用本文复制引用
何玉慧,李响,石军..鱼类肌肉生长研究进展[J].水产学报,2024,48(9):1-21,21.基金项目
国家重点研发计划(2023YFD240203) （2023YFD240203）
农业生物育种重大项目(2023ZD04054) （2023ZD04054）
广州市农村科技特派员项目(2023E04J1242) National Key Research and Development Program of China(2023YFD240203) （2023E04J1242）
Biological Breeding-Major Projects(2023ZD04054) （2023ZD04054）
Guangzhou Rural Science and Technology Commissioner Project(2023E04J1242) （2023E04J1242）
