miR-27a-3p在肺腺癌中的表达及其生物学功能OACSTPCD
Expression and Biological Functions of miR-27a-3p in Lung Adenocarcino-ma
目的:本研究旨在检测miR-27a-3p在肺腺癌中的表达水平,及其对肺腺癌细胞恶性生长和迁移的影响及分子机制.方法:整合公共数据分析miR-27a-3p在肺腺癌中的表达水平和预后价值.以肺腺癌细胞为研究对象,通过转染inhibitor降低miR-27a-3p水平,EdU检测细胞增殖活性,Transwell小室检测细胞迁移,实时荧光定量PCR检测miR-27a-3p和其靶基因水平.结果:miR-27a-3p在肺腺癌中呈显著高表达(P＜0.05),且…查看全部>>
Objective:The aim of this study was to detect the expression level of miR-27a-3p in lung adenocarcinoma(LUAD),and study the effect of miR-27a-3p on the malignant growth and migration of LUAD cells.Methods:The expres-sion level and prognostic value of miR-27a-3p in LUAD were analyzed by integrating public datasets.Inhibitor was transfect-ed to decrease the level of miR-27a-3p in LUAD cells.Cell proliferation activity was detected by EdU,cell migration was de-…查看全部>>
牛静静;张文桃;畅靖嘉;张昕彤;朱剑军
710061 西安,西安市胸科医院病理科030001 太原,山西医科大学基础医学院030001 太原,山西医科大学基础医学院030001 太原,山西医科大学基础医学院030001 太原,山西医科大学基础医学院
生物学
miR-27a-3p肺腺癌细胞迁移细胞增殖
miR-27a-3pLung adenocarcinomaCell migrationCell proliferation
《肿瘤预防与治疗》 2024 (8)
641-648,8
中国博士后科学基金(编号:2023M732157)山西省基础研究计划项目(编号:202303021211114)山西医科大学校级博士启动基金(编号:XD1808) This study was supported grants from China Postdoctoral Science Foundation(No.2023M732157),Science and Technology Department of Shanxi Province(No.202303021211114),and Shanxi Medical University(No.XD1808).
评论