山东医药2024，Vol.64Issue(25)：11-15,5.DOI:10.3969/j.issn.1002-266X.2024.25.003
血清CCL5、P2X7R水平与大血管闭塞性急性缺血性脑卒中并发恶性脑水肿的关系
Predictive value of serum CCL5 and P2X7R levels in acute ischemic stroke with large vessel occlusion complicated with malignant brain edema
摘要
Abstract
Objective To investigate the predictive value of serum levels of C-C motif chemokine ligand 5(CCL5)and purinergic 2X7 receptor(P2X7R)in acute ischemic stroke with large vessel occlusion(AIS LVO)complicated with malignant cerebral edema(MBE).Methods Totally 162 patients with AIS-LVO(observation group)were selected.After receiving intravenous thrombolysis combined with mechanical thrombectomy,43 cases with MBE and 119 cases without MBE were diagnosed 72 h later,and 60 healthy volunteers were selected as the control group during the same period.Periph-eral venous blood of all subjects was collected,serum was collected by centrifugation,and serum CCL5 and P2X7R were de-tected by ELISA.Multivariate Logistic regression model was used to analyze the risk factors of AIS-LVO complicated with MBE,and receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum CCL5 and P2X7R levels in AIS-LVO complicated with MBE.Results The serum levels of CCL5 and P2X7R in the observation group were higher than those in the control group(both P<0.05).Univariate analysis showed that NIHSS score,ASPECTS score and serum CCL5 and P2X7R levels of AIS-LVO patients with MBE were higher than those of AIS-LVO patients without MBE(all P<0.05).Multivariate Logistic regression analysis showed that the increase of NIHSS score and serum CCL5 and P2X7R levels were independent risk factors for AIS-LVO complicated with MBE(all P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum CCL5 and P2X7R levels independently and jointly in predicting AIS-LVO complicated with MBE were 0.780,0.790 and 0.880,respectively.The AUC of serum CCL5 and P2X7R combined in predicting AIS-LVO complicated with MBE was greater than that of either alone(both P<0.05).Conclusions Increased levels of serum CCL5 and P2X7R are independent risk factors for AIS-LVO complicated with MBE.Serum CCL5 and P2X7R levels have certain predictive value for AIS-LVO complicated MBE,and the combined detection of the two has a higher predictive value.关键词
大血管闭塞性急性缺血性脑卒中/恶性脑水肿/C-C基序趋化因子配体5/嘌呤能2X7受体Key words
large vessel occlusive acute ischemic stroke/malignant cerebral edema/C-C motif chemokine ligand 5/purinergic 2X7 receptor分类
医药卫生引用本文复制引用
王菲,张娟利,苏航,赵毅..血清CCL5、P2X7R水平与大血管闭塞性急性缺血性脑卒中并发恶性脑水肿的关系[J].山东医药,2024,64(25):11-15,5.基金项目
陕西省中医药管理局委托办事经费项目(2021-ZZ-LC033). （2021-ZZ-LC033）
