温阳健脾方调节AMPK/mTOR/ULK1通路上调RSA小鼠孕期自噬水平改善其蜕膜化的机制研究OACSTPCD
Study on the mechanism of Wenyang Jianpi decoction regulating AMPK/mTOR/ULK1 pathway,up-regulating autophagy level in RSA mouse during pregnancy and improving decidualization
目的:探讨温阳健脾方通过影响 AMPK/mTOR/ULK1 信号轴调控 RSA 小鼠孕期自噬水平,从而对其蜕膜化影响的机制研究.方法:CBA/J 雌鼠与 BALB/c 雄鼠合笼建立空白组 10 只,CBA/J 雌鼠与 DBA/2 雄鼠合笼建立 RSA小鼠模型,随机将其分为模型组、温阳健脾方中剂量组,10 只/组;于妊娠第 1 天开始,温阳健脾方组予温阳健脾方 13.96 g/(kg·d)灌胃,空白组及模型组予以等体积 0.9%氯化钠溶液,连续干预…查看全部>>
Objective:To study the influence of Wenyang Jianpi decoction on autophagy level of recurrent spon-taneous abortion(RSA)mice during pregnancy by influencing AMPK/mTOR/ULK1 signal axis.Methods:5 CBA/J female rats and BALB/c male rats were caged to establish 10 normal control rats.CBA/J female mice were caged with DBA/2 male mice to establish RSA mouse model,which were randomly divided into model group and middle dose group of Wenyang Jianpi decoction,wit…查看全部>>
赵贵霜;刘娟;李孟瑶;姜丽娟
云南中医药大学第一临床医学院,云南 昆明 650000云南中医药大学第一临床医学院,云南 昆明 650000云南中医药大学第一临床医学院,云南 昆明 650000云南中医药大学第一附属医院伦理委员会,云南 昆明 650021
临床医学
复发性流产自噬蜕膜化温阳健脾方AMPK/mTOR/ULK1信号通路阴阳平衡胰岛素样生长因子结合蛋白1催乳素
Recurrent spontaneous abortionAutophagyDecidualizationWenyang Jianpi decoctionSignaling pathway of AMPK/mTOR/ULK1The balance of yin and yangInsulin-like growth factor-1Prolactin
《陕西中医》 2024 (9)
1155-1160,6
国家自然科学基金地区科学基金资助项目(82060882)
评论