陕西中医2024，Vol.45Issue(9)：1218-1221,4.DOI:10.3969/j.issn.1000-7369.2024.09.015
龙胆泻肝丸联合鼓室内注射倍他米松治疗分泌性中耳炎疗效研究
Efficacy of Longdan Xiegan pill combined with intratympanic injection of betamethasone in the treatment of secretory otitis media
摘要
Abstract
Objective:To investigate the clinical efficacy of Longdan Xiegan pill combined with intratympanic in-jection of betamethasone in the treatment of secretory otitis media(OME)and its effect on the levels of high mobili-ty group protein 1(HMGB1),tumor necrosis factor-α(TNF)-α and interleukin(IL)-33 in peripheral blood T lym-phocyte subsets and middle ear effusion.Methods:A total of 252 OME patients were randomly divided into two groups with 126 patients in each group.The control group was treated with betamethasone injection in tympanic chamber.On this basis,the observation group was treated with Longdan Xiegan pill.The clinical efficacy,levels of HMGB1,TNF-α and IL-33 in peripheral blood T lymphocyte subsets and middle ear effusion were compared between the two groups.Results:The total effective rate of 91.37%in the observation group was higher than that of 82.54%in the control group(P<0.05).After treatment,disease severity score,mean audibility threshold of air conduction,mean audibility threshold of bone conduction,HMGB1,TNF-α and IL-33 levels of peripheral blood CD8+and middle ear effusion were significantly decreased in both groups,while peripheral blood CD3+,CD4+and CD4+/CD8+levels were significantly increased,especially in the observation group(P<0.05).The adverse reaction rate was 10.3%in the observation group and 8.7%in the control group(P>0.05).Conclusion:The overall efficacy of Longdan Xiegan pill combined with betamethasone injection in tympanic cavity in the treatment of OME is accurate,and it can im-prove the hearing of patients,improve the imbalance of peripheral blood T lymphocyte subgroups,and inhibit the ex-pression of HMGB1,TNF-α and IL-33 in middle ear effusions,with good safety.关键词
分泌性中耳炎/龙胆泻肝丸/鼓室内注射治疗/倍他米松/T淋巴细胞亚群/中耳积液/炎症因子Key words
Secretory otitis media/Longdan Xiegan pill/Intratympanic injection therapy/Betamethasone/T-lymphocyte subsets/Middle ear effusion/Inflammatory factors分类
医药卫生引用本文复制引用
袁萍,刘敏,刘建兵,康厚墉..龙胆泻肝丸联合鼓室内注射倍他米松治疗分泌性中耳炎疗效研究[J].陕西中医,2024,45(9):1218-1221,4.基金项目
重庆市卫生和计划生育委员会中医药科技项目(ZY201802143) （ZY201802143）
