陕西中医2024，Vol.45Issue(9)：1226-1229,4.DOI:10.3969/j.issn.1000-7369.2024.09.017
清肠解毒方联合化疗治疗晚期结直肠癌疗效及对患者预后的影响
Clinical effect and prognosis of Qingchang Jiedu formula combined with chemotherapy in the treatment of patients with advanced colorectal cancer
摘要
Abstract
Objective:To observe the clinical effect and prognosis of Qingchang Jiedu formula combined with chemotherapy in the treatment of patients with advanced colorectal cancer(CRC)(internal dampness-heat accumula-tion syndrome type).Methods:A total of 67 patients with advanced CRC(internal dampness-heat accumulation syn-drome type)who underwent chemotherapy were divided into the control group(n=32)and the traditional Chinese medicine group(n=35),the control group were treated with conventional chemotherapy,the traditional Chinese medicine group were treated with self-made Qingchang Jiedu formula combined with chemotherapy.Therapeutic effects,expression levels of tumor markers,serum factor level,and prognosis were observed compared and the inci-dence of adverse reactions during treatment were statistically analyzed.Results:The total effective rate between the two groups was no significant difference(P>0.05).After treatment,the expression levels of carcinoembryonic anti-gen(CEA),carbohydrate antigen 125(CA125)and carbohydrate antigen 199(CA199)in both groups decreased,and the levels of traditional Chinese medicine group decreased significantly(P<0.05).After treatment,both groups showed significant reductions in WBC,PLT,and NEUT.Compared with the control group,the traditional Chinese medicine group showed less decrease in WBC and PLT,and more decrease in NEUT(P<0.05).As of January 2024,the median follow-up time of the traditional Chinese medicine group and the control group was 27.3 months and 28.5 months,respectively.OS and PFS of the traditional Chinese medicine group were significantly longer than those of the control group(P<0.05).The incidence rates of gastrointestinal adverse reactions,liver and kidney function dam-age,and neurological toxicity in the traditional Chinese medicine group were significantly lower(P<0.05).Conclusion:Qingchang Jiedu formula combined with chemotherapy can effectively improve the expression levels of tumor mark-ers and serum factor level,and prolong OS and PFS of patients with advanced CRC,with good safety.关键词
晚期结直肠癌/清肠解毒方/湿热内蕴证/疗效/肿瘤标志物/炎症水平/预后Key words
Advanced colorectal cancer/Qingchang Jiedu formula/Internal dampness-heat accumulation syn-drome/Therapeutic effect/Tumor marker/Inflammation level/Prognosis分类
医药卫生引用本文复制引用
周鹏飞,董晓琳,查名宝..清肠解毒方联合化疗治疗晚期结直肠癌疗效及对患者预后的影响[J].陕西中医,2024,45(9):1226-1229,4.基金项目
安徽省卫生健康委员会科研项目(AHWJ2022A060) （AHWJ2022A060）
