陕西中医2024，Vol.45Issue(9)：1274-1277,4.DOI:10.3969/j.issn.1000-7369.2024.09.029
《世医得效方》中消渴病用药规律探讨
Research on the medication rules of formula for diabetes in World Medical Achievement Formula based on data mining
摘要
Abstract
Objective:Using the data mining technology,this paper analyzed the medication rules of the prescrip-tion recorded in"the medicine of the world Medicine".Methods:To summarize the prescriptions for the treatment of diabetes in the"World Medical Achievement Formula",and the database of prescriptions for diabetes was established by Excel 2016 software and Traditional Chinese medicine inheritance support system,TCMISS(V2.5).Using data mining technology,the frequency,attribute and efficacy of traditional Chinese medicine were analyzed statistically,and the correlation analysis and cluster analysis were carried out.Results:There are a total of 50 prescriptions for the treatment of diabetes,including 118 flavors of Chinese herbs,Top 4 high frequency drugs are Panax ginseng C.A.Meyer,White poria,Coptis chinensis Franch.,Trichosanthes kirilowii Maxim.The medicinal properties are mainly cold,and the medicinal flavoris mainly sweet.The first meridian attributions are spleen,and the frequency of deficien-cy tonifying drugs was the highest.There were 7 groups of high-frequency drug use patterns,among which the top 4 groups in order of frequency were Panax ginseng C.A.Meyer-White poria,Schisandra chinensis-White poria,Radix Ophiopogonis-Panax ginseng C.A.Meyer,Panax ginseng C.A.Meyer-Glycyrrhiza uralensis Fisch.The drug associa-tion rules with confidence≥0.6,in order of frequency,Radix Ophiopogonis→Panax ginseng C.A.Meyer,Schisandra chinensis→Radix Rehmanniae Preparata,Radix Rehmanniae Preparata→Schisandra chinensis,Schisandra chinensis→Panax ginseng C.A.Meyer,etc.The unsupervised entropy-based hierarchical clustering algorithm yielded a total of four potential new formula combinations for the treatment of diabetes,namely Moschus moschiferus L.-Rhizoma Di-oscoreae Oppositae-Poria cocos-Cinnabaris,Cuscuta chinensis Lam.-Dendrobium nobile Lindl.-Colla Cornus Cervi-Lignum Aquilariae Resinatum,Astragali Radix-Polygala tenuifolia Willd.-Poria cocos-Cinnabaris,Moschus moschi-ferus L.-Radix Aucklandiae-Platycodon grandiflorus-Poria cocos-Cinnabaris.Conclusion:Through the analysis of the medication law of the prescription for treating diabetes in"World Medical Achievement Formula",it was found that the treatment follows the principle of Yin deficiency of thirst and heat as the target pathogenesis,nourishing Yin through sweet and cold is the key point in the treatment of diabetes,meanwhile,taking into account tonifying spleen and kidney,tonifying lung and promoting fluid,etc.,the compatibility drugs are mainly deficiency tonifying drugs and heat-clearing drugs,which can provide theoretical reference for modern clinical rational and effective drug use.关键词
《世医得效方》/数据挖掘/消渴/中医药/用药规律/中医传承辅助平台Key words
World Medical Achievement Formula/Data mining/Diabetes/Traditional Chinese Medicine/Rules of medication/Traditional Chinese medicine inheritance support system分类
医药卫生引用本文复制引用
杨家蕾,孙晔..《世医得效方》中消渴病用药规律探讨[J].陕西中医,2024,45(9):1274-1277,4.基金项目
国家自然科学基金资助项目(81973599) （81973599）
