陕西中医2024，Vol.45Issue(9)：1294-1296,封3,4.DOI:10.3969/j.issn.1000-7369.2024.09.034
基于足细胞上皮-间充质转化探讨中医药对慢性肾脏疾病作用机制及研究进展
To explore the mechanism and research progress of traditional Chinese medicine on chronic kidney disease based on podocyte epithelial-mesenchymal transformation
摘要
Abstract
As highly specialized epithelial cells with high energy requirements of the kidney,podocytes are es-sential for keeping the integrity of the glomerular filtration barrier.Epithelial-mesenchymal transdifferentiation is an important form of podocyte injury,which easily leads to glomerular filtration dysfunction and affects the occurrence and progression of many chronic kidney diseases.Chinese herbs such as Astragali Radix,Tripterygium wilfordii Hook.f.,Panax notoginseng,Isaria cicadae can inhibit the epithelial-mesenchymal transformation of podocytes through TGF-β1/Smad,Wnt/β-catenin,Notch and other signaling pathways,thus playing a role in protecting the kid-ney.Therefore,this study aims to review the mechanism of action and research progress of traditional Chinese medi-cine in the treatment of chronic kidney diseases from the perspective of podocyte epithelial-mesenchymal transforma-tion,in order to provide scientific basis for the application of traditional Chinese medicine in the clinical treatment of chronic kidney diseases.关键词
足细胞上皮-间充质转化/信号通路/慢性肾脏疾病/中医药/作用机制/研究进展Key words
Podocyte epithelial-mesenchymal transformation/Signal pathway/Chronic kidney diseases/Tradi-tional Chinese medicine/Action mechanism/Research progress分类
医药卫生引用本文复制引用
张炜捷,朱戎..基于足细胞上皮-间充质转化探讨中医药对慢性肾脏疾病作用机制及研究进展[J].陕西中医,2024,45(9):1294-1296,封3,4.基金项目
国家自然科学基金资助项目(81873245) （81873245）
