miR-1290对非酒精性脂肪性肝病的调控机制研究OACSTPCD
Regulatory mechanism of miR-1290 in non-alcoholic fatty liver disease
目的 探讨miRNAs是否参与非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的发病过程以及miR-1290对NAFLD GH/IGF1轴调控的可能机制.方法 通过GenBank GEO数据库,Targetscan、mirBase、miRanda等miRNA生物数据库以及大量文献阅读筛选出在NAFLD中异常表达的miRNAs,再通过GO和KEGG分析靶基因预测软件筛选出与GH/IGF1轴基因相关…查看全部>>
Objective To explore the role and potential regulatory mechanism of miR-1290 in non-alcoholic fatty liver disease(NAFLD).Methods GenBank GEO database,Targetscan,mirBase,miRanda biological databases were screened to find out miRNAs abnormally expressions in NAFLD,and GO and KEGG analysis target gene prediction databases were used to select miRNAs related to GH-IGF1 axis.NAFLD was induced in HL-7702(L02)cells to establish L02 NAFLD cell line.L02 cells(control …查看全部>>
邹琳;孙菲;李映璇;陈霞;马俊花
上海市浦东新区公利医院内分泌科,上海 200135上海市浦东新区公利医院内分泌科,上海 200135上海市浦东新区公利医院内分泌科,上海 200135上海市浦东新区公利医院内分泌科,上海 200135上海市浦东新区公利医院内分泌科,上海 200135
临床医学
非酒精性脂肪性肝病miRNAs胰岛素抵抗脂代谢GH/IGF1轴
non-alcoholic fatty liver diseasemiRNAsinsulin resistancelipid metabolismGH/IGF1 axis
《同济大学学报（医学版）》 2024 (4)
488-495,8
上海市浦东新区卫生系统优秀青年医学人才培养计划(PWRq2020-30)上海市卫生健康委员会项目(202040315)上海市浦东新区公利医院青年英才基金(GLRq2018-02)
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