同济大学学报（医学版）2024，Vol.45Issue(4)：510-515,6.DOI:10.12289/j.issn.2097-4345.24016
超声造影联合剪切波弹性成像对无症状颈动脉斑块患者缺血性脑卒中的预测价值
Predictive value of contrast-enhanced ultrasonography combined with shear wave elastography for risk of ischemic stroke in patients with asymptomatic carotid plaques
摘要
Abstract
Objective To investigate the predictive value of contrast-enhanced ultrasonography(CEUS),combined with shear wave elastography(SWE)for risk of ischemic stroke in patients with asymptomatic carotid plaques.Methods Clinical and imaging data of 90 patients with carotid plaques who underwent CEUS and SWE examinations were retrospectively analyzed.Patients were followed up for 180 d.Ischemic stroke occurred in 8 cases(stroke group),did not occur in 82 cases(non-stroke group).Univariate and multivariate Cox regression were used to analyze the predictors of ischemic stroke events,and a nomogram was developed based on above risk factors to predict the incidence of stroke.Cumulative incidence was evaluated using the Kaplan-Meier survival analysis.Receiver operating characteristic(ROC)curve was generated to analyze the value of each index in assessing the risk of ischemic stroke.Results The risk of ischemic stroke in patients with grade 2 intraplaque neovascularization(IPN)and lower shear wave velocity(SWV)was higher than those with grade 0-1 IPN and higher SWV(P＜0.001,P=0.025).Multivariate Cox regression showed that IPN and SWV were independent risk factors for predicting ischemic stroke in carotid plaque patients(P=0.045,P=0.028).The nomogram developed based on IPN and SWV had good discrimination effect(C-index=0.898).ROC curve showed that the AUC of the nomogram for predicting risk of ischemia strok was 0.897.According to the cutoff value,patients were divided into low-risk group and high-risk group,the risk of ischemic stroke in high-risk group was higher than that in low-risk group(P＜0.001).Conclusion The combination of IPN and SWV demonstrates good predictive value for the risk of ischemic stroke in asymptomatic patients with carotid plaques.关键词
缺血性脑卒中/颈动脉斑块/新生血管/弹性/超声Key words
ischemic stroke/carotid plaque/neovascularization/elasticity/ultrasound分类
医药卫生引用本文复制引用
张璐妮,贾彩霞,顾诗瑶,陈静,吴蓉..超声造影联合剪切波弹性成像对无症状颈动脉斑块患者缺血性脑卒中的预测价值[J].同济大学学报（医学版）,2024,45(4):510-515,6.基金项目
国家自然科学基金重点项目(82130057) （82130057）
国家自然科学基金(82202176) （82202176）
