同济大学学报（医学版）2024，Vol.45Issue(4)：516-520,5.DOI:10.12289/j.issn.2097-4345.24200
孕产期D-二聚体变化与产后肺栓塞发生的关系
Relationship between changes of D-dimer levels during pregnancy and risk for postpartum pulmonary embolism
摘要
Abstract
Objective To explore the relationship between the change of D-dimer during pregnancy and the occurrence of postpartum pulmonary embolism.Methods The clinical data of 279 pregnant women who were registered for antenatal check-up and delivery in Obstetrics and Gynecology Hospital of Tongji University from January 2018 to January 2023 were analyzed retrospectively.Plasma D-dimer levels were dynamically detected and documented.Postpartum pulmonary embolism occurred in 104 cases(case group),pregnant women without pulmonary embolism served as control group(n=168).The relationship between the changes of D-dimer levels during pregnancy and the occurrence of postpartum pulmonary embolism was analyzed.Results There was no significant difference in conception mode,maternal height,weight and BMI,and the number of fetal arrest between the case group and the control group(P＞0.05).There were significant differences in age,number of births,gravidity and parity(P＜0.05)between two groups.There was higher proportion of pregnant women with older age,multiple births and multiple births in the case group.The plasma D-dimer levels were elevated with the increase of gestational age in the case group.The postpartum D-dimer levels in the case group were significantly higher than those in the control group(Z=-4.520,P＜0.05);while there were no significant differences in D-dimer levels at time of registration and pre-delivery period(Z=-0.669,P=0.504;Z=-0.804,P=0.421)between two groups).The higher postpartum D-dimer levels(6.325-18.25 mg/L)were associated with the risk of pulmonary embolism.Conclusion The levels of plasma D-dimer during pregnancy and childbirth show an increasing trend.The changes of plasma D-dimer during postpartum period may increase the risk of the occurrence of postpartum pulmonary embolism.关键词
静脉血栓栓塞症/D-二聚体/产后肺栓塞Key words
venous thromboembolism/D-dimer/postpartum pulmonary embolism分类
医药卫生引用本文复制引用
刘倩倩,郁君,吴桂珠..孕产期D-二聚体变化与产后肺栓塞发生的关系[J].同济大学学报（医学版）,2024,45(4):516-520,5.基金项目
上海市科学技术委员会医学创新项目(22Y11906200) （22Y11906200）
