世界中医药2024，Vol.19Issue(15)：2339-2345,7.DOI:10.3969/j.issn.1673-7202.2024.15.022
中医药干预早期非小细胞肺癌的临床效果研究
Clinical Efficacy of TCM Intervention in Early-stage Non-small Cell Lung Cancer
摘要
Abstract
Objective:To analyze the factors influencing disease-free survival in early-stage non-small cell lung cancer(NSCLC)patients after radical surgery and observe the impact of traditional Chinese medicine(TCM)intervention on these patients.Meth-ods:A single-arm,single-center retrospective study was conducted on clinical data of 415 early-stage NSCLC patients who received TCM intervention.Kaplan-Meier method was used for univariate analysis of potential prognostic factors for early-stage NSCLC.Fac-tors with significant results determined by significance testing were further analyzed using Cox regression to establish a Cox propor-tional hazards model.Results:The 1-year,2-year,3-year,5-year,and 10-year disease-free survival rates of 415 patients with early-stage NSCLC were 96.1％,87.5％,84.0％,76.5％,and 67.4％,respectively.Univariate analysis indicated that gender,age,smoking history,surgical method,pathological type,clinical stage,TCM syndrome differentiation,TCM medication and non-medica-tion treatment duration,blank period of TCM intervention,and the duration of comprehensive TCM intervention were significant prognostic factors(P＜0.05).Cox regression analysis identified gender,clinical stage,TCM syndrome differentiation,duration of Chinese patent medicine treatment,and duration of comprehensive TCM treatment as independent risk factors.Conclusion:TCM in-terventions could improve disease-free survival rates and prognosis in early-stage NSCLC patients.Among these patients,those who were female,younger,non-smokers,underwent video-assisted thoracoscopic surgery,had lung adenocarcinoma(predominantly lepid-ic subtype),early clinical stage,and TCM syndromes of qi and yin deficiency or lung and spleen qi deficiency had better outcomes.A shorter TCM intervention blank period and prolonged comprehensive TCM treatment contributed to increased disease-free survival rates.关键词
中医药/非小细胞肺癌/根治术后/复发转移/预后因素/无病生存期/生存分析/疗效Key words
Traditional Chinese medicine/Non-small cell lung cancer/After radical surgery/Recurrence and metastasis/Prog-nostic factors/Disease-free survival/Survival analysis/Curative effect分类
医药卫生引用本文复制引用
杨昕,管懋莹,陆恩昊,李和根,周蕾,徐蔚杰,朱丽华,肖凌,侯宛昕,封佳莉,黄弦歌..中医药干预早期非小细胞肺癌的临床效果研究[J].世界中医药,2024,19(15):2339-2345,7.基金项目
国家自然科学基金项目(8237150337,82205214) （8237150337,82205214）
上海市临床重点专科(中医)建设项目(shslczdzk03701)——中医肿瘤 （中医）
上海市中医肿瘤临床医学研究中心项目名称(21MC1930500) （21MC1930500）
