基于骨免疫学论中医药抑制类风湿关节炎骨破坏的研究进展OA北大核心CHSSCDCSTPCD

Rheumatoid arthritis(RA)is an autoimmune disease characterized by synovitis,cartilage,and bone destruction,with a high rate of disability.The immune and inflammatory responses in RA interact with bone cell metabolism,with a key mechanism in-volving the imbalance in the receptor activator of nuclear factor-κB ligand(RANKL)/RANK/osteoprotegerin(OPG)signaling path-way.This imbalance leads to decreased osteoblasts and increased osteoclast apoptosis and abnormal activation.While western medi-cine primarily focuses on inhibiting inflammatory responses and related cytokine secretion to slow disease progression,long-term use is associated with notable adverse effects.Research into traditional Chinese medicine(TCM)for preventing and treating bone de-struction in RA has advanced,but both basic and clinical research still face certain limitations.