世界中医药2024，Vol.19Issue(15)：2352-2356,5.DOI:10.3969/j.issn.1673-7202.2024.15.024
基于骨免疫学论中医药抑制类风湿关节炎骨破坏的研究进展
Traditional Chinese Medicine in Inhibiting Bone Destruction in Rheumatoid Arthritis Based on Bone Immunology Theory:A Review
摘要
Abstract
Rheumatoid arthritis(RA)is an autoimmune disease characterized by synovitis,cartilage,and bone destruction,with a high rate of disability.The immune and inflammatory responses in RA interact with bone cell metabolism,with a key mechanism in-volving the imbalance in the receptor activator of nuclear factor-κB ligand(RANKL)/RANK/osteoprotegerin(OPG)signaling path-way.This imbalance leads to decreased osteoblasts and increased osteoclast apoptosis and abnormal activation.While western medi-cine primarily focuses on inhibiting inflammatory responses and related cytokine secretion to slow disease progression,long-term use is associated with notable adverse effects.Research into traditional Chinese medicine(TCM)for preventing and treating bone de-struction in RA has advanced,but both basic and clinical research still face certain limitations.关键词
骨免疫学/中医药/类风湿关节炎/骨破坏/炎症反应/核因子κB受体活化因子/核因子κB受体活化因子配体/骨保护素Key words
Bone immunology/Traditional Chinese medicine/Rheumatoid arthritis/Bone destruction/Inflammatory responses/Receptor activator of nuclear factor kappa-B/Receptor activator of nuclear factor kappa-B ligand/Osteoprotegerin分类
医药卫生引用本文复制引用
夏璇,陈杰君,张磊,王茂杰,黄闰月,储永良..基于骨免疫学论中医药抑制类风湿关节炎骨破坏的研究进展[J].世界中医药,2024,19(15):2352-2356,5.基金项目
国家自然科学基金面上项目(82274421) （82274421）
广东省中医院中医药科学技术研究专项(YN2020QN16) （YN2020QN16）
