世界中医药2024，Vol.19Issue(15)：2363-2370,8.DOI:10.3969/j.issn.1673-7202.2024.15.026
基于PI3K/AKT信号通路探讨中药治疗激素性股骨头坏死的研究进展
Chinese Medicine in the Treatment of Steroid-induced Femoral Head Necrosis Based on PI3K/AKT Signaling Pathway:A Review
摘要
Abstract
Hormone-induced femoral head necrosis is the most common type of non-traumatic femoral head necrosis,accounting for up to 1/3 of such cases.Current treatments are inadequate in effectively delaying the progression of this disease,and hip replace-ment surgery often becomes the only option for advanced cases.Therefore,developing a new hip-preserving treatment to alleviate the suffering and economic burden on patients is an urgent challenge.Recent research has shown a close connection between the phos-phatidylinositol 3-kinase/protein kinase B(PI3K/AKT)signaling pathway and hormone-induced femoral head necrosis.Medications targeting the PI3K/AKT signaling pathway have demonstrated significant efficacy in treating this condition.Chinese herbal medi-cine,a hallmark of traditional Chinese medicine(TCM)science,offers multi-target,low-cost,and low-side-effect therapies.With the ongoing advancement in TCM pharmacology,many Chinese herbal monomers and formulas with functions such as tonifying the kid-neys,strengthening bones,activating blood circulation,and resolving blood stasis have been proven effective in treating hormone-in-duced femoral head necrosis through the regulation of the PI3K/AKT signaling pathway.关键词
激素性股骨头坏死/中药单体/中药复方/药理研究进展/PI3K/AKT信号通路/内皮细胞/成骨细胞/破骨细胞Key words
Steroid-induced femoral head necrosis/Chinese herbal monomers/Chinese herbal formulas/Advances in pharmaco-logical studies/PI3K/AKT signaling pathway/Endothelial cells/Osteoblasts/Osteoclasts分类
医药卫生引用本文复制引用
封潇添,杨培川,李光,马天成,崔洪伟,王祺钰,马信龙,马剑雄,王岩,申佳慧,周丽芸,李奕扬,孙亚迪,董本超,李岩..基于PI3K/AKT信号通路探讨中药治疗激素性股骨头坏死的研究进展[J].世界中医药,2024,19(15):2363-2370,8.基金项目
国家重点研发计划项目(2022YFC3601904) （2022YFC3601904）
天津市自然科学基金重点项目(22JCZDJC00340) （22JCZDJC00340）
