水生生物学报2024，Vol.48Issue(9)：1592-1602,11.DOI:10.7541/2024.2024.0116
胆汁酸调节鱼类糖脂代谢、免疫及肠道菌群的研究进展
RESEARCH PROGRESS ON THE REGULATION OF FISH GLYCOLIPID METABOLISM,IMMUNITY AND INTESTINAL FLORA BY BILE ACIDS
摘要
Abstract
Bile acids(BAs)constitute a class of amphipathic sterol compounds,categorized into primary and secondary bile acids based on their origins.Primary bile acids are synthesized from cholesterol in the liver and subsequently enter the intestine.In the intestine,primary bile acids undergo conversion into secondary bile acids by the intestinal flora,primarily in the terminal ileum and upper colon.The majority of bile acids in the intestine are returned to the liver through enterohepatic circulation in the ileum,while the remaining bile acids are excreted with feces.Research shows the significant role of bile acids in maintaining glycolipid homeostasis,improving immune function,and reshaping intestinal flora in fish.However,the composition,classification,and functions of bile acids in different fish species remain poorly understood.This article provides a comprehensive summary of bile acid composition,classification,main receptors,biological functions,and the current state of research and challenges in understanding bile acids in fish.The aim is to offer insights for further investigation into fish bile acids and their efficient utilization in aquaculture prac-tices.关键词
胆汁酸/糖脂代谢/免疫调控/肠道菌群/鱼类养殖Key words
Bile acids/Glycolipid metabolism/Immune regulation/Intestinal flora/Fish breeding分类
生物科学引用本文复制引用
周茜,张俊炜,王升鹏,李超伟,陈松林..胆汁酸调节鱼类糖脂代谢、免疫及肠道菌群的研究进展[J].水生生物学报,2024,48(9):1592-1602,11.基金项目
山东省"泰山学者青年专家"项目(tsqn202306295) （tsqn202306295）
山东龙昌动物保健品股份有限公司项目(20223702050376)资助[Supported by the Shandong Provincial"Taishan Scholar Young Experts"Program(tsqn202306295) （20223702050376）
Shandong Longchang Animal Health Products Co.,Ltd.Program(20223702050376)] （20223702050376）
