创面组织再生修复材料的安全性和有效性评价技术研究进展OA北大核心CSTPCD

Newly developed biomedical materials for tissue regeneration and repair can promote cell proliferation and immigration in wounds,accelerate wound healing,and enhance healing quality.With the development of these new materials,the traditional evaluation method and technology are no longer completely applicable.Therefore,the recent progress of research on characterization,biosafety,and effectiveness evaluation of newly developed materials for wound tissue regeneration and repair was summarized.The chemical property,degradation and absorption,physical property,and biocompatibility evaluation requirement of the materials were introduced,and the established effectiveness evaluation technology was described,including in vitro cell proliferation,cell immigration,in vitro barrier protection,and microangiogenesis tests,as well as in vivo animal wound modeling and wound healing effectiveness evaluation method.