石油化工2024，Vol.53Issue(8)：1205-1217,13.DOI:10.3969/j.issn.1000-8144.2024.08.019
基于仿生控冰材料的生物安全冷冻保存策略
Biosafety cryopreservation strategies based on bionic ice-control materials
摘要
Abstract
As cryopreservation technology is a vital means of maintaining the viability of cells,tissues,and organs,the realization of safe and effective cryopreservation will bring about a historic change in bioscience and clinical medical research.Traditional small-molecule cryoprotectants,such as dimethyl sulfoxide(DMSO),play an important role in cryopreservation.However,their structural disruption and biotoxicity at the molecular,subcellular,cellular,as well as tissue,organ,and individual levels have greatly limited their application in cryopreservation.This study discussed and summarized the toxicity of DMSO and the novel ice-control materials.Current researchers are trying to explore those materials in the field of cryopreservation,especially a series of bionic ice-control materials with good biocompatibility inspired by cold-resistant organisms in extreme environments in nature.The development of the ice-control materials was outlined.The advantages and challenges of the novel ice-control materials were analyzed,such as the bionic ice-control materials,in the cryopreservation of biological samples.Meanwhile,the study looked forward to the future development trend.关键词
冷冻保存/二甲基亚砜/生物相容性/冰结合蛋白/仿生控冰材料/冷冻保护剂Key words
cryopreservation/dimethyl sulfoxide/biocompatibility/ice-binding proteins/bionic ice-control materials/cryoprotectants分类
化学化工引用本文复制引用
王凌琪,刘樟,王健君..基于仿生控冰材料的生物安全冷冻保存策略[J].石油化工,2024,53(8):1205-1217,13.基金项目
国家自然科学基金项目(T2293760) （T2293760）
国家杰出青年科学基金项目(51929307). （51929307）
