实用医学杂志2024，Vol.40Issue(17)：2363-2368,6.DOI:10.3969/j.issn.1006-5725.2024.17.002
BTK抑制剂治疗套细胞淋巴瘤的临床研究进展
Clinical research progress of BTK inhibitors in the treatment of mantle cell lymphoma
摘要
Abstract
Mantle cell lymphoma(MCL)is a rare B-cell non-Hodgkin's lymphoma characterized by clini-cal and pathological features encompassing both indolent and aggressive subtypes.Significant progress has been made in the past decade regarding the development of novel therapeutic options for MCL.Particularly,Bruton's tyrosine kinase inhibitor(BTKi)has exhibited remarkable efficacy in treating patients with MCL by specifically targeting the BTK protein,thereby inhibiting B-cell proliferation and inducing potent anti-tumor effects.Currently,global approval has been granted to five BTK inhibitors for MCL treatment,including the first-generation Ibrutinib,second-generation Acalabrutinib,Zanubrutinib,Orelabrutinib,as well as the non-covalent BTKi Pirtobrutinib.This review provides a comprehensive summary of findings from clinical trials investigating the use of BTKi in MCL treatment and offers valuable insights for clinical practice.关键词
BTK抑制剂/复发/难治/套细胞淋巴瘤/靶向治疗Key words
BTK inhibitor/relapsed/refractory/mantle cell lymphoma/targeted therapy分类
医药卫生引用本文复制引用
徐思诗,叶佩佩..BTK抑制剂治疗套细胞淋巴瘤的临床研究进展[J].实用医学杂志,2024,40(17):2363-2368,6.基金项目
浙江省医药卫生科技计划项目(编号:2024KY1601,2024KY1602) （编号:2024KY1601,2024KY1602）
