实用医学杂志2024，Vol.40Issue(17)：2390-2394,5.DOI:10.3969/j.issn.1006-5725.2024.17.006
宫腔粘连分离术后冻融周期囊胚移植对妊娠结局的影响
Strategy for frozen-thawed cycle blastocyst transfer after hysteroscopic adhesiolysis
摘要
Abstract
Objective To explore the assisted reproductive strategy and influencing factors for patients undergoing frozen-thawed cycle blastocyst transfer after hysteroscopic adhesiolysis for intrauterine adhesions.Methods A total of 275 patients who underwent frozen-thawed cycle blastocyst transfer after hysteroscopic adhesiolysis for infertility reasons at the Reproductive Genetics Center of the First Affiliated Hospital of University of Science and Technology of China from January 2018 to December 2022 were included in the study.They were divided into a single blastocyst transfer group(n=182)and a double blastocyst transfer group(n=93).The clinical outcomes were analyzed and compared retrospectively between the group.Results The two groups showed no statis-tically significant differences in terms of age,day of endometrial thickness conversion,endometrial preparation method,clinical pregnancy rate,miscarriage rate,preterm birth rate,gestational week at delivery,and mode of delivery(P>0.05).The single blastocyst transfer group had significantly lower infertility duration(years)(2.43±1.64 vs.3.03±2.13,P<0.05),significantly lower AFS prognosis score(5.13±2.25 vs.5.72±2.19,P<0.05),and significantly lower multiple pregnancy rate(1.33%vs.28.57%,P<0.05),but significantly higher quality embryo rate(90.66%vs.46.24%,P<0.05),implantation rate(50.00%vs.34.41%,P<0.05),and live infant mass(g)(3236.84±565.35 vs.2976.44±692.79,P<0.05)compared to the double blastocyst transfer group.Binary logistic regression analysis showed that the number of high-quality embryos transferred and AFS score were independent influencing factors for clinical pregnancy(P<0.05).Conclusions The number of high-quality embryos transferred and the AFS score are independent influencing factors for clinical pregnancy in patients undergoing frozen-thawed cycle blastocyst transfer after hysteroscopic adhesiolysis for intrauterine adhesions.Single high-quality blastocyst transfer is a preferred treatment for patients after hysteroscopic adhesiolysis,and double blastocyst transfer is favor-able for patients with a poor prognosis to achieve better pregnancy outcomes.关键词
宫腔粘连/冻融周期/囊胚/因素/妊娠结局Key words
intrauterine adhesion/frozen-thawed cycle/blastocyst/factors/pregnancy outcome分类
医药卫生引用本文复制引用
刘程,桑美英,方群英,白顺,胡美红,郑圣霞..宫腔粘连分离术后冻融周期囊胚移植对妊娠结局的影响[J].实用医学杂志,2024,40(17):2390-2394,5.基金项目
国家自然科学基金项目(编号:81971339) （编号:81971339）
