Enhancing the Photosensitivity of Hypocrellin A by Perylene Diimide Metallacage-Based Host-Guest Complexation for Photodynamic TherapyOACSTPCDEI
Enhancing the Photosensitivity of Hypocrellin A by Perylene Diimide Metallacage-Based Host-Guest Complexation for Photodynamic Therapy
The development of supramolecular hosts which can efficiently encapsulate photosensitizers to improve the photodynamic effficacy holds great promise for cancer therapy.Here,we report two perylene diimide-based metallacages that can form stable host-guest complexes with planar conjugated molecules including polycyclic aromatic hydrocarbons and photosensitizers(hypocrellin A).Such host-guest complexation not only prevents the aggregation of photosensitizers in aqueous environments,but also offers fluorescence resonance energy transfer(FRET)from the metallacage to the photosensitizers to further improve the singlet oxygen generation(ΦΔ=0.66).The complexes are further assembled with amphiphilic polymers,forming nanoparticles with improved stability for anticancer study.Both in vitro and in vivo studies indicate that the nanoparticles display excellent anticancer activities upon light irradiation,showing great potential for cancer photodynamic therapy.This study provides a straightforward and effective approach for enhancing the photosensitivity of conventional photosensitizers via host-guest complexation-based FRET,which will open a new avenue for host-guest chemistry-based supramolecular theranostics.
Rongrong Li;Mingming Zhang;Tianfeng Yang;Xiuhong Peng;Qian Feng;Yali Hou;Jiao Zhu;Dake Chu;Xianglong Duan;Yanming Zhang
State Key Laboratory for Mechanical Behavior of Materials,Shaanxi International Research Center for Soft Matter,School of Materials Science and Engineering,Xi'an Jiaotong University,Xi'an 710049,People's Republic of China||School of Pharmacy,Health Science Center,Xi'an Jiaotong University,Xi'an 710061,People's Republic of ChinaState Key Laboratory for Mechanical Behavior of Materials,Shaanxi International Research Center for Soft Matter,School of Materials Science and Engineering,Xi'an Jiaotong University,Xi'an 710049,People's Republic of ChinaSchool of Pharmacy,Health Science Center,Xi'an Jiaotong University,Xi'an 710061,People's Republic of ChinaState Key Laboratory for Mechanical Behavior of Materials,Shaanxi International Research Center for Soft Matter,School of Materials Science and Engineering,Xi'an Jiaotong University,Xi'an 710049,People's Republic of China||Department of Rehabilitation Medicine,Shaanxi Provincial People's Hospital,Xi'an 710068,Shaanxi,People's Republic of ChinaDepartment of Gastroenterology,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,People's Republic of ChinaDepartment of Rehabilitation Medicine,Shaanxi Provincial People's Hospital,Xi'an 710068,Shaanxi,People's Republic of China
MetallacagesHost-guest interactionsFluorescence resonance energy transferSinglet oxygenPhotodynamic therapy
《纳微快报（英文）》 2024 (011)
71-87 / 17
This work was supported by the National Natural Science Foundation of China(22171219 and 22222112),Innovation Talent Promotion Plan of Shaanxi Province for Science and Technology Innovation Team(2023-CX-TD-51),Key Laboratory Fund for Plasma Physics(6142A04210108),the Interdisciplinary Training Program for Doctoral Candidate of Xi'an Jiaotong University(IDT2105),and National Natural Science Foundation NSAF Joint Fund(U2230112).We thank Dr.Gang Chang and Dan He at Instrument Analysis Center and Dr.Aqun Zheng and Junjie Zhang at Experimental Chemistry Center of Xi'an Jiaotong University for NMR and fluorescence measurements.We thank Menghan Sun from Shiyanjia Lab(www.shiyanjia.com)for the X-ray crystal structure analysis and electron spin resonance measurements.We also acknowledge the mass spectrometry characterization provided by the members of Molecular Scale Lab at Shenzhen University.
评论