端粒长度与子宫内膜异位症的因果关系:双向孟德尔随机研究OACSTPCD

Objective:Based on the large-scale population-based genome-wide associa-tion study(GWAS),Mendelian randomization(MR)analysis was used to explore whether there was a causal relationship between telomere length(TL)and endometriosis(EMs).Methods:Two-way MR was used to study the GWAS summary statistics of TL(77257 sam-ples)and EMs(472174 samples)from European ancestry.MR analysis was performed using inverse variance weighting(IVW),MR-Egger,weighted median,simple model and weighted model.The results were mainly based on IVW,using random effects and sensitivity analysis.Heterogeneity was detected by IVW and MR-Egger.The level detection was analyzed by MR-Egger.Single nucleotide polymorphisms(SNPs)were identified by leave-one-out method.Re-sults:The results of IVW forward MR analysis showed that TL had a significant effect on EMs(IVW OR=1.250,P=0.006).No significant causal relationship between EMs and TL was found in reverse MR analysis(IVW OR=0.997,P=0.569).These findings are robust in sev-eral sensitivity analyses.Conclusion:There is a causal relationship between TL and EMs,and there is a positive correlation.No causal association between EMs and TL was found by reverse MR analysis.