现代妇产科进展2024，Vol.33Issue(9)：666-669,674,5.DOI:10.13283/j.cnki.xdfckjz.2024.09.031
端粒长度与子宫内膜异位症的因果关系:双向孟德尔随机研究
Causal relationship between telomere length and endometriosis:a two-way Mendelian random study
摘要
Abstract
Objective:Based on the large-scale population-based genome-wide associa-tion study(GWAS),Mendelian randomization(MR)analysis was used to explore whether there was a causal relationship between telomere length(TL)and endometriosis(EMs).Methods:Two-way MR was used to study the GWAS summary statistics of TL(77257 sam-ples)and EMs(472174 samples)from European ancestry.MR analysis was performed using inverse variance weighting(IVW),MR-Egger,weighted median,simple model and weighted model.The results were mainly based on IVW,using random effects and sensitivity analysis.Heterogeneity was detected by IVW and MR-Egger.The level detection was analyzed by MR-Egger.Single nucleotide polymorphisms(SNPs)were identified by leave-one-out method.Re-sults:The results of IVW forward MR analysis showed that TL had a significant effect on EMs(IVW OR=1.250,P=0.006).No significant causal relationship between EMs and TL was found in reverse MR analysis(IVW OR=0.997,P=0.569).These findings are robust in sev-eral sensitivity analyses.Conclusion:There is a causal relationship between TL and EMs,and there is a positive correlation.No causal association between EMs and TL was found by reverse MR analysis.关键词
端粒长度/子宫内膜异位症/孟德尔随机化,因果关系Key words
Telomere length/Endometriosis/Mendelian randomization,causal relationship分类
医药卫生引用本文复制引用
杨亚楠,姜学文,黄欲晓,亢一帆,崔楠,赵嘉静,张雨晴,朱友华,张瑜娟,方梦鑫,卜梦雅..端粒长度与子宫内膜异位症的因果关系:双向孟德尔随机研究[J].现代妇产科进展,2024,33(9):666-669,674,5.基金项目
中国中医科学院"优势病种-医院制剂-新药"研发专项(No:ZZ15-XY-PT-04) （No:ZZ15-XY-PT-04）
中国中医科学院科技创新工程(No:CI2021A02411) （No:CI2021A02411）
中国中医科学院西苑医院中药新药研发专项(No:XYZX0303-05) （No:XYZX0303-05）
