现代医药卫生2024，Vol.40Issue(17)：2881-2887,7.DOI:10.3969/j.issn.1009-5519.2024.17.001
新型炎症指数在糖尿病肾病患者全因死亡中的预测价值
Predictive value of new inflammatory index in all-cause mortality in patients with diabetic kidney disease
摘要
Abstract
Objective To explore the predictive effect of a new inflammatory index based on multiple peripheral blood indicators on all-cause mortality in patients with diabetic kidney disease(DKD).Methods The clinical data of DKD population in 10 cycles from 1999 to 2018 in the National Health and Nu-trition Examination Survey(NHANES)database were analyzed.Univariate and multivariate Cox regression analysis were uesd to explore the correlation between four new inflammatory indexes,including systemic im-mune inflammatory index(SII),neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),monocyte to lymphocyte ratio(MLR)and all-cause mortality in DKD patients.The accuracy of each index in predicting all-cause mortality in DKD patients was evaluated by the area under time-dependent receiver operat-ing characteristic curve(AUC).Results A total of 2 043 participants were included,with a median age of 70 years.SII,NLR,PLR and MLR were significantly associated with all-cause mortality in DKD patients(RR at Q4=1.61,1.61,1.28,1.62,95%CI 1.35-1.95,1.32-1.97,1.07-1.53,1.32-2.00,P<0.001,P<0.001,P=0.007,P<0.001).The AUC of SII,NLR,MLR and PLR were 67.68%,59.10%,58.31%and 61.89%,respectively.Conclusion Four new inflammatory indices are significantly associated with all-cause mortality in DKD patients.The new inflammatory index has predictive value for the follow-up of DKD patients.关键词
糖尿病肾病/新型炎症指数/全因死亡/预测Key words
Diabetic nephropathy/New inflammatory index/All-cause death/Prediction分类
医药卫生引用本文复制引用
李春蒙,廖晓辉..新型炎症指数在糖尿病肾病患者全因死亡中的预测价值[J].现代医药卫生,2024,40(17):2881-2887,7.基金项目
国家自然科学基金面上项目(81873604) （81873604）
重庆市自然科学基金面上项目(CSTB2022NSCQ-MSX0984) （CSTB2022NSCQ-MSX0984）
重庆市科卫联合项目(2022GDRC005). （2022GDRC005）
