儿童迁延性细菌性支气管炎远期预后影响因素分析OA

Objective To explore the long-term prognosis of children with protracted bacterial bronchi-tis(PBB),and to provide reference for the clinical diagnosis and treatment of PBB.Methods The general da-ta,clinical manifestations,auxiliary examinations and treatment plans of 123 children with clinical diagnosis of PBB admitted to the hospital from April 2018 to May 2021 were collected.The patients were followed up for 25-62 months after discharge(median follow-up time was 38 months)to understand and analyze the progno-sis of children with PBB.According to whether there was a recurrence of wet cough(wet cough)after dis-charge,they were divided into the symptomatic group(46 cases)and the cured group(77 cases).The patients were divided into the recurrent group(19 cases)and the non-recurrent group(104 cases)according to wheth-er there was recurrent PBB(PBB attack>3 times/year).Results During the follow-up period,37.4%(46/123)of the children developed wet cough again,15.4%(19/123)were diagnosed as recurrent PBB,and 1.6%(2/123)were diagnosed as bronchiectasis.Compared with the cured group,the proportion of neutrophils in bronchoalveolar lavage fluid,the proportion of spontaneous delivery,the proportion of asthma and upper air-way cough syndrome in the symptomatic group were significantly increased,and the differences were statisti-cally significant(P<0.05).The proportion of lymphocytes in bronchoalveolar lavage fluid in the recurrent group was significantly lower than that in the non-recurrent group,and the proportion of asthma was signifi-cantly higher than that in the non-recurrent group,the differences were statistically significant(P<0.05).Conclusion Nearly one-third of children with PBB will have wet cough again after discharge,and the frequency and proportion of wet cough will gradually decrease with time each year.A small number of children will have recurrent PBB,and a very small number of children will progress to bronchiectasis.