接种三剂新冠病毒灭活疫苗后抗新冠病毒抗体动态变化研究OA

Objective To explore the dynamic changes of anti-coronavirus antibodies in medical staff of intensive care unit after three doses of novel coronavirus inactivated vaccine,and to dynamically evaluate their immune status.Methods A total of 30 medical staff in intensive care unit who received three doses of inacti-vated SARS-CoV-2 vaccine in this hospital from November 2020 to November 2021 were selected as the re-search objects.Venous blood samples were collected at 0,1,3,6 and 12 months after inoculation of novel coro-navirus vaccine to detect the titer of anti-novel,coronavirus antibody immunoglobulin G,lymphocyte subsets and cytokines,and the changes were analyzed.Results Anti-coronavirus antibodies were positive in 30 medical staff one month after injection of three doses of inactivated coronavirus vaccine,and the titer increased signifi-cantly in the first month,with statistically significant difference(P<0.05).In the first month,the anti-neo-coronavirus antibody reached a peak and then gradually decreased.In the 12th month,the anti-neo-coronavirus antibody was still higher than that in the 0 th month,and the difference was statistically significant(P<0.05).There was no significant difference in lymphocyte subsets at different time points(P>0.05).After in-oculation with the novel coronavirus inactivated vaccine,interleukin-2(IL-2),IL-10,interferon-γ,and tumor necrosis factor-α all showed inverted U-shaped changes,IL-6 showed U-shaped changes,and IL-4 showed fluc-tuating changes.Conclusion The three-dose inactivated vaccine can produce a higher level of antibody and maintain a high titer for at least six months.