牛结节性皮肤病免疫抗体监测的Meta分析OA北大核心CSTPCD

Vaccination is an essential measure in preventing lumpy skin disease(LSD).However,the induction of humoral immune responses post-vaccination varies,and there is currently a lack of effective methods to evaluate vaccine immunogenicity.This study employed Meta-analysis using R software to statistically analyze published data on immune antibody monitoring for LSD,including subgroup analyses,to comprehensively assess the significance of immune antibody monitoring.A computer search was conducted in both Chinese and English databases,including CNKI,Wanfang Data,VIP,PubMed,and Web of Science.The search was up to July 2023,col-lecting relevant studies on immune antibody monitoring for LSD.Based on predetermined inclu-sion and exclusion criteria,a total of 24 articles were included.Among these,13 articles were re-lated to sheep/goat pox vaccine,and 13 articles were related to LSD vaccine.Two articles cov-ered both sheep/goat pox and lumpy skin disease vaccines,with a total of 8,638 samples,inclu-ding 2,782 positive samples.The outcome measure was the positive rate of immune antibodies.Meta-analysis results indicated an immune antibody level of 41％(95％CI:27％～55％)for sheep/goat pox vaccine and 73％(95％CI:64％～86％)for LSD vaccine.The homogeneity among studies was low,and there was no significant difference between the two vaccines(P=0.59).The literature related to sheep/goat pox vaccination(P=0.12)and LSD vaccination(P=0.077)both suggested no apparent publication bias.Subgroup analysis was based on immuniza-tion sites and detection methods,the mesults showed that there were no significant differences between different immunization sites(P=0.84)or detection methods(P=0.40),indicated non-heterogeneity in both subgroups.These findings suggest that there is significant uncertainty in e-valuating immune protection effectiveness using immune antibody monitoring methods,compre-hensive analysis and judgment will be necessitating in practical applications.