医疗卫生装备2024，Vol.45Issue(8)：63-67,5.DOI:10.19745/j.1003-8868.2024155
直肠癌不同放疗技术下肛门括约肌及其亚结构的剂量学比较
Dosimetric comparison of anal sphincter and its substructures with different radiotherapy techniques for rectal cancer
摘要
Abstract
Objective To compare the dosimetric effects of volume modulated arc therapy(VMAT)and intensity modulated radiation therapy(I M RT)on the anal sphincter(AS)and its sub-structures in neoadjuvant radiotherapy for rectal cancer to facilitate the selection of radiotherapy techniques.Methods Fifty rectal cancer patients receiving neoadjuvant radiotherapy were selected,and 2 types of radiotherapy plans,including coplanar double full-arc VMAT and coplanar seven-field homo-geneous IMRT,were designed based on the CT images of the patients,respectively.Under the premise of ensuring that the irradiated doses to the target area and the major organs at risk reached the standard and met the clinical requirements,AS and its substructures were added as the organs at risk for dosimetric evaluation.The absolute dose parameters and relative dose parameters of AS and its substructures were counted by dose-volume histograms.Statistical analysis was performed using IBM SPSS 22.0 software.Results The VMAT plan had the relative dose parameters V20,V30,and V40 of AS and its substructures lower those of the IMRT plan,the differences were statistically significant(P＜0.05),while the differences in V5 and V 10 were not statistically significant(P＞0.05).The VMAT plan had the absolute dose parameterDmeanlower while the D2％slightly higher than those of the IMRT plan,the differences were statistically significant(P＜0.05).The difference in D98％between the two plans was not statistically significant(P＞0.05).Conclusion During rectal cancer radiotherapy VMAT generally behaves better than IMRT in protecting AS and its sub-structures and decreasing injuries of AS and its sub-structures dosimetrically.[Chinese Medical Equipment Journal,2024,45(8):63-67]关键词
直肠癌/容积旋转调强放疗/调强放疗/肛门括约肌/剂量学Key words
rectal cancer/volume modulated arc therapy/intensity modulated radiation therapy/anal sphincter/dosimetry分类
医药卫生引用本文复制引用
李耿,邓飞,李拥军,丰大利,李鑫,孔卓,王吉萍,邹敏..直肠癌不同放疗技术下肛门括约肌及其亚结构的剂量学比较[J].医疗卫生装备,2024,45(8):63-67,5.基金项目
湖北省老年胃肠癌精准防治临床医学研究中心开放基金项目(2022EGC-12,2022EGC-08,2022EGC-05) （2022EGC-12,2022EGC-08,2022EGC-05）
宜昌市医疗卫生研究项目(A24-2-040) （A24-2-040）
