云南化工2024，Vol.51Issue(8)：33-36,4.DOI:10.3969/j.issn.1004-275X.2024.08.07
3-氯-4-氟苯胺的合成及其应用
Synthesis and Application of 3-chlorine-4-flunaniline
艾祖国 1范吉霞 2李一明 2李兴 2字慧敏 2田强2
作者信息
- 1. 云南云天化股份有限公司研发中心,云南 昆明 650228||昆明理工大学化学工程学院,云南 昆明 650093
- 2. 云南云天化股份有限公司研发中心,云南 昆明 650228
- 折叠
摘要
Abstract
The demand of 3-chlorine 4-floanidine as an important synthetic raw material of fluflox,citafloxacin,afatinib,and its production scale increase year by year.This article provides an overview of the advancements in the synthesis technology of 3-chloro-4-fluoraniline,in-cluding its application prospects,synthesis routes,specific materials used in each step,and variations in reaction progress.Furthermore,it delves into the synthetic classification of 3-chloro-4-fluoraniline as a pharmaceutical pesticide intermediate.The advantages and disadvanta-ges of different raw materials,synthetic measures and experimental methods are summarized to provide reference for the follow-up experimental research.关键词
3-氯-4-氟苯胺/硝化/氟化/还原/合成Key words
3-chloro-4-fluoroaniline/Nitration/Fluorination/Reduction/Synthetize分类
化学工程引用本文复制引用
艾祖国,范吉霞,李一明,李兴,字慧敏,田强..3-氯-4-氟苯胺的合成及其应用[J].云南化工,2024,51(8):33-36,4.
