摘要
Abstract
Objective To study the efficacy of YISAIPU(rh TNFR:Fc)combined with sulfasalazine(SASP)in the treatment of ankylosing spondylitis(AS)and its effect on serum inflammatory factors.Methods Eighty AS patients admitted to Ji'an County People's Hospital from January 2022 to June 2023 were included and divided into control group(40 patients)and observation group(40 patients)by random number table method.The control group was treated with rh TNFR:Fc,and the observation group was treated with SASP on the basis of rh TNFR:Fc.The clinical efficacy,symptom improvement(spinal pain degree,morning stiffness time),serum inflammatory factors[erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)],prognosis and rehabilitation[Bath Ankylosing Spondylitis Disease Activity Index(BASDAI),Bath Ankylosing Spondylitis Functional Index(BASFI)]were compared between the two groups.Results The ASAS20 compliance rate of the observation group at 1 and 3 months of treatment was higher than that of the control group(P＜0.05).After treatment,the score of spinal pain in the two groups decreased,and the time of morning stiffness was shortened,while the score of spinal pain in the observation group was lower than that in the control group,and the time of morning stiffness was shorter than that in the control group(P＜0.05).The levels of ESR and CRP in the two groups after treatment were lower than those before treatment,and the levels of ESR and CRP in the observation group were lower than those in the control group(P＜0.05).After treatment,the BASDAI and BASFI scores of the two groups were lower than those before treatment,and the BASDAI and BASFI scores of the observation group were lower than those of the control group(P＜0.05).Conclusion rh TNFR:Fc combined with SASP is effective in the treatment of ankylosing spondylitis,which can improve the clinical efficacy of patients,relieve their symptoms and inflammatory reactions,and improve the prognosis.关键词
强直性脊柱炎/益赛普/柳氮磺吡啶/血清炎性因子/脊柱疼痛/晨僵症状Key words
Ankylosing spondylitis/YISAIPU/Sulfasalazine/Serum inflammatory factors/Spinal pain/Morning stiffness symptoms分类
临床医学
