诊断学理论与实践2024，Vol.23Issue(3)：313-317,5.DOI:10.16150/j.1671-2870.2024.03.009
缺血性心力衰竭患者N端脑钠肽前体与新发房颤的相关性研究
Association between NT-proBNP and new-onset atrial fibrillation in patients with ischemic heart failure
摘要
Abstract
Objective To investigate the association between N-terminal pro-brain natriuretic peptide(NT-proBNP)levels and the incidence of new-onset atrial fibrillation(AF)in patients with ischemic heart failure.Methods This study in-volved 120 patients with ischemic heart failure,characterized by sinus rhythm and a reduced ejection fraction(EF<40%).NT-proBNP levels were measured at baseline,6 months,and 12 months.At the 12-month follow-up,patients underwent 12-lead electrocardiography(EKG)or Holter monitoring to identify new-onset AF.Patients were classified into an AF group(n=44)and a non-AF group(n=76).Clinical characteristics and echocardiographic data were reviewed.Receiver operating characteristic(ROC)curves were employed to ascertain the optimal NT-proBNP threshold for predicting new-onset AF,and logistic regression analysis was used to evaluate the prognostic impact of NT-proBNP levels.Results New-onset AF was de-tected in 36.7%of the cohort.Significant elevations in functional capacity(NYHA class),NT-proBNP levels,E/A ratio,E/E'ratio,pulmonary artery systolic pressure(PASP),pulmonary capillary wedge pressure(PCWP),left atrial volume(LAV),and left atrial volume index(LAVI)were observed in the AF group compared to the non-AF group(P<0.05).NT-proBNP levels demonstrated positive correlations with these echocardiographic parameters(P<0.05).ROC curve analysis identified a baseline NT-proBNP cutoff value of 2357 pg/mL as the most predictive of new-onset AF,with 69%sensitivity and 83%specificity(AUC=0.825,95%CI:0.722-0.924,P<0.001).Logistic regression analysis further established NT-proBNP as the only independent predictive predictor of new-onset AF(OR=1.24,95%CI:1.08-1.43,P=0.001).Conclusions Serum NT-proBNP level is of certain value in prediction of the new-onset AF in patients with ischemic heart failure.关键词
N端脑钠肽前体/射血分数降低的心衰/缺血性心肌病/新发心房颤动Key words
N-terminal pro-brain natriuretic peptide/Heart failure with low ejection fraction/Ischemic cardiomyopathy/New-onset atrial fibrillation分类
医药卫生引用本文复制引用
罗晓颖,章安迪,许燕,吴立群,戚文航..缺血性心力衰竭患者N端脑钠肽前体与新发房颤的相关性研究[J].诊断学理论与实践,2024,23(3):313-317,5.基金项目
国家自然科学基金青年项目(81500196) （81500196）
