敲减miR-296-5p通过激活ACE2信号通路减轻脑梗死后神经功能损伤OA北大核心CSTPCD
Knockdown of miR-296-5p alleviates nerve function damage after cere-bral infarction by activating ACE2 signaling pathway
目的:探究微小RNA-296-5p(miR-296-5p)对脑梗死(CI)后神经功能损伤的影响及其与血管紧张素转换酶2(ACE2)信号通路介导的内皮祖细胞(EPC)活力的调节关系.方法:选取本院70例确诊为CI且伴有神经功能损伤的患者血清标本(CI组)和70例健康志愿者的血清标本(健康组),RT-qPCR法检测两组血清miR-296-5p、ACE2和Mas mRNA的表达.构建大鼠CI模型,将SD大鼠随机分为健康对照组、模型对照组、sh-miR-…查看全部>>
AIM:To explore the effect of microRNA-296-5p(miR-296-5p)on neurological damage after cere-bral infarction(CI)and its regulatory relationship with angiotensin-converting enzyme 2(ACE2)signaling pathway medi-ated proliferation of endothelial progenitor cell(EPC).METHODS:Serum samples from 70 patients diagnosed with CI and accompanied by neurological damage in our hospital(CI group)and 70 healthy volunteers(healthy group)were se-lected.The mRNA expression of mi…查看全部>>
李吉博;肖端偶;贺斌;徐峰;冯永文
深圳市光明区人民医院,广东 深圳 518106深圳市光明区人民医院,广东 深圳 518106深圳市光明区人民医院,广东 深圳 518106深圳市光明区人民医院,广东 深圳 518106深圳市光明区人民医院,广东 深圳 518106
基础医学
微小RNA-296-5p血管紧张素转换酶2内皮祖细胞脑梗死神经功能损伤
microRNA-296-5pangiotensin converting enzyme 2endothelial progenitor cellscerebral in-farctionneurological impairment
《中国病理生理杂志》 2024 (8)
1455-1462,8
深圳市科技计划项目(No.JCYJ20220530165217040)
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