中国当代儿科杂志2024，Vol.26Issue(9)：921-925,5.DOI:10.7499/j.issn.1008-8830.2405033
儿童原发性肾病综合征并发急性肾损伤的早期识别
Early identification of acute kidney injury in children with primary nephrotic syndrome
摘要
Abstract
Objective To investigate the incidence and risk factors for acute kidney injury(AKI)in children with primary nephrotic syndrome(PNS),as well as the role of neutrophil gelatinase-associated lipocalin(NGAL)and kidney injury molecule-1(KIM-1)in the early identification of AKI in these children.Methods A prospective collection of clinical data from children hospitalized with PNS at the Children's Hospital of the Capital Institute of Pediatrics from January 2021 to October 2022 was conducted.The children were divided into two groups based on the presence of AKI:the AKI group(47 cases)and the non-AKI group(169 cases).The risk factors for AKI in children with PNS were identified by multivariate logistic regression analysis.Urinary KIM-1 and NGAL levels were compared between the AKI and non-AKI groups,as well as among the different stages of AKI.Results The incidence of AKI in children with PNS was 21.8%.Multivariate logistic regression analysis revealed that steroid-resistant nephrotic syndrome,gastrointestinal infections,and heavy proteinuria were independent risk factors for AKI in these children with PNS(P<0.05).Urinary KIM-1 and NGAL levels were higher in the AKI group compared to the non-AKI group(P<0.05),and the urinary NGAL and KIM-1 levels in the AKI stage 2 and stage 3 subgroups were higher than those in the AKI stage 1 subgroup(P<0.017).Conclusions KIM-1 and NGAL can serve as biomarkers for the early diagnosis of AKI in children with PNS.Identifying high-risk populations for AKI in children with PNS and strengthening the monitoring of related risk factors is of significant importance.关键词
原发性肾病综合征/急性肾损伤/中性粒细胞明胶酶相关脂质运载蛋白/肾脏损伤因子1/儿童Key words
Primary nephrotic syndrome/Acute kidney injury/Neutrophil gelatinase-associated lipocalin/Kidney injury molecule-1/Child引用本文复制引用
高洁,陈朝英,涂娟,耿海云,李华荣,孙金山,王楠楠,黄永莉..儿童原发性肾病综合征并发急性肾损伤的早期识别[J].中国当代儿科杂志,2024,26(9):921-925,5.基金项目
北京市医院管理中心"青苗"计划专项经费资助(QML20201309). （QML20201309）
