中国当代儿科杂志2024，Vol.26Issue(9)：933-939,7.DOI:10.7499/j.issn.1008-8830.2404090
短肽型全肠内营养疗法对克罗恩病患儿体格生长及营养状态的影响
Impact of short-peptide exclusive enteral nutrition therapy on physical growth and nutritional status in children with Crohn's disease
摘要
Abstract
Objective To evaluate the clinical efficacy of short-peptide exclusive enteral nutrition(EEN)therapy in inducing remission during active Crohn's disease(CD)in children,as well as changes in physical growth and nutritional indicators before and after treatment.Methods A prospective study included 43 children with active CD who were admitted to the Department of Gastroenterology,Children's Hospital of Nanjing Medical University from January 2017 to January 2024.The participants were randomly divided into a medication treatment group(13 children)and a short-peptide+medication treatment group(30 children).The changes in the Pediatric Crohn's Disease Activity Index(PCDAI)scores,physical growth,and nutritional indicators before and after treatment were analyzed in both groups.Results The PCDAI scores in the short-peptide+medication treatment group were lower than those in the medication treatment group after treatment(P<0.05).The Z-scores for weight-for-age,body mass index,and albumin levels were higher in the short-peptide+medication treatment group compared to the medication treatment group(P<0.05).In the patients with moderate to severe CD,total protein levels in the short-peptide+medication treatment group were significantly higher than those in the medication treatment group(P<0.05).Conclusions Short-peptide EEN therapy can induce clinical remission in children with active CD and promote their physical growth while improving their nutritional status.关键词
克罗恩病/短肽/全肠内营养/体格生长/营养状态/儿童Key words
Crohn's disease/Short-peptide/Exclusive enteral nutrition/Physical growth/Nutritional status/Child引用本文复制引用
杨敏,吴润秋,陈文馨,乔雪,杨辉..短肽型全肠内营养疗法对克罗恩病患儿体格生长及营养状态的影响[J].中国当代儿科杂志,2024,26(9):933-939,7.基金项目
南京市科技发展项目(201605045). （201605045）
