中国防痨杂志2024，Vol.46Issue(9)：1050-1055,6.DOI:10.19982/j.issn.1000-6621.20240165
重症肺结核患者病原学阳性率及利福平耐药结果分析
Analysis of bacteriological positivity and rifampicin resistance in patients with severe pulmonary tuberculosis
摘要
Abstract
Objective:To assess the bacteriological positivity rate and rifampicin resistance in sputum samples from patients with severe pulmonary tuberculosis.Methods:A retrospective analysis was conducted on 369 cases of pulmonary tuberculosis admitted to Beijing Chest Hospital,Capital Medical University,between January and December 2023,including 145 severe and 224 non-severe cases.The positive detection rates of Mycobacterium tuberculosis(MTB)in sputum samples were evaluated using acid-fast staining smear microscopy(smear),BACTEC MIGT 960 culture(culture),and Xpert MTB/RIF(Xpert).Rifampicin resistance was also assessed.Results:In severe pulmonary tuberculosis,the positive rates for smear,culture,and Xpert tests,as well as the overall bacteriological positivity rate,were 47.41％(55/116),68.75％(77/112),85.82％(115/134),and 80.69％(117/145),respectively.In non-severe cases,these rates were 29.44％(63/214),53.17％(109/205),68.35％(149/218),and 71.43％(160/224),respectively.The differences between severe and non-severe cases were statistically significant(x2=10.580,P=0.001;=7.250,P=0.007;x2=12.512,P＜0.001;=4.034,P=0.045).There was no significant difference in rifampicin resistance rates between patients with severe pulmonary tuberculosis and those with non-severe cases(11.30％(13/115)vs.8.05％(12/149);x2=0.800,P=0.371).However,rifampicin resistance rates were higher in previously treated cases compared to new cases among Xpert-positive patients(24.24％(8/33)vs.6.10％(5/82);x2=7.727,P=0.005).Conclusion:Patients with severe pulmonary tuberculosis exhibited a higher bacteriological positivity rate;however,there was no significant difference in rifampicin resistance rates between severe and non-severe cases.Rifampicin resistance rates were notably higher in previously treated cases compared to newly diagnosed cases.关键词
结核,肺/微生物学技术/抗药性,细菌Key words
Tuberculosis,pulmonary/Microbiological techniques/Drug resistance,bacterial分类
医药卫生引用本文复制引用
耿子妹,王潮虹,龙嗣博,郑迈克,施亦衡,孙勇,赵艳,王桂荣..重症肺结核患者病原学阳性率及利福平耐药结果分析[J].中国防痨杂志,2024,46(9):1050-1055,6.基金项目
Beijing Public Health Experts Project(2022-3-040) （2022-3-040）
Beijing Tongzhou Municipal Science and Technology Commission(KJ2023CX038) 北京市高层次公共卫生技术人才项目(2022-3-040) （KJ2023CX038）
北京市通州区科技计划项目(KJ2023CX038) （KJ2023CX038）
