中国临床心理学杂志2024，Vol.32Issue(4)：935-940,6.DOI:10.16128/j.cnki.1005-3611.2024.04.039
团体运动干预对孤独症谱系障碍儿童肠道菌群的影响
Effects of Group Exercise Intervention on Gut Microbiota in Children with Autism Spectrum Disorders
摘要
Abstract
Objective:To investigate the differences in gut microbiota between children with autism spectrum disorder(ASD)and healthy immediate family members,and the effects of group exercise intervention on gut microbiota and behavior in autistic children.Methods:4 children with ASD participated in exercise intervention for 15 times and 1 hour each time.The control was 8 healthy immediate family members.16S rRNA high-throughput sequencing was used to analyze the intes-tinal microbiota in children with ASD before and after exercise intervention.Changes in behavioral symptoms of children with ASD were further evaluated by Autism Treatment Evaluation Checklist.Results:The abundance of Erysipelotrichace-ae in children with ASD was significantly higher than that in typical developmental siblings before intervention,and there was no significant decrease after exercise intervention.In addition,the abundance ratio of Firmicutes to Bacteroidetes in children with ASD obviously declined after exercise intervention.Interestingly,the sociability of children with ASD im-proved after exercise intervention,and there was a significant positive correlation with bacterial Bacteroidetes.Conclusion:The abundance of harmful bacteria in children with ASD is significantly higher than typical developing siblings.Exercise in-tervention is beneficial to the improvement of social function of children with ASD by increasing the abundance of Bacte-roidetes.关键词
孤独症谱系障碍/运动干预/团体干预/肠道菌群Key words
Autism spectrum disorder/Exercise intervention/Group intervention/Gut microbiota分类
医药卫生引用本文复制引用
赵凡,张池,何木叶,韩宏岩,贾凤芹,刘电芝..团体运动干预对孤独症谱系障碍儿童肠道菌群的影响[J].中国临床心理学杂志,2024,32(4):935-940,6.基金项目
国家社会科学基金项目"自闭症儿童分阶综合运动训练模式探索及效果评估"(19BTY129) （19BTY129）
江苏省教育科学规划项目"孤独症儿童认知灵活性的特点及干预研究"(C/2023/01/80). （C/2023/01/80）
