中国临床药理学杂志2024，Vol.40Issue(16)：2325-2328,4.DOI:10.13699/j.cnki.1001-6821.2024.16.005
不同疗程枸橼酸咖啡因治疗极低出生体质量儿的临床研究
Clinical trial of different courses of caffeine citrate in the treatment of very low birth weight infants
赵燕凤 1杨飞 1周晓媚 2叶林 1常晓雯 1叶仙丽 1王艳1
作者信息
- 1. 杭州市妇产科医院,新生儿科,浙江杭州 310008
- 2. 杭州市妇产科医院,药剂科,浙江杭州 310008
- 折叠
摘要
Abstract
Objective To compare the efficacy and safety of different courses of caffeine citrate injection in the treatment of very low birth weight infants.Methods Very low birth weight infants were divided into long course group and routine course according to cohort method.2 groups of children were given intravenous infusion of caffeine citrate injection loading dose(20 mg·kg-1)within 3 days after birth,and the dose was maintained at 5 mg·kg-1 after 24 hours(qd).In the long course group,caffeine citrate injection was used to correct gestational age＞34 weeks,and in the routine course,caffeine citrate injection was used to correct gestational age 33-34 weeks.The use of caffeine citrate injection,clinical efficacy,neonatal behavioral neurological scale(NBNA)score and the occurrence of adverse drug reactions were compared between the two groups.Results 116 cases were included in this study,64 cases in the long course group and 52 cases in the routine course.After treatment,the total clinical effective rate of the long course group and the routine course was 92.19％and 94.23％,respectively,with no statistical significance(P＞0.05).The total duration of caffeine citrate injection were(60.53±8.92)and(48.17±5.24)days,respectively;the corrected gestational age at withdrawal were(36.02±1.56)and(33.18±1.27)weeks,respectively.The corrected gestational age were(34.31±0.48)and(32.06±0.51)weeks;the milk volume were(32.69±2.14)and(23.85±1.69)mL,respectively,with statistical significance(all P＜0.05).The starting age of caffeine citrate injection were(59.65±3.42)and(58.35±3.11)h in the long course group and the routine course,respectively,with no statistical significance(P＞0.05).Before treatment,the NBNA score of the long course and routine courses were 36.49±6.78 and 35.58±4.22,respectively;the NBNA score of long course and conventional course after treatment were 43.25±6.88 and 44.12±7.42,respectively.Compared with before treatment,NBNA score in both groups were higher after treatment,with statistical significance(all P＜0.05).There was no significant difference in NBNA score between the long course group and the routine course(P＞0.05).The incidence of bronchopulmonary dysplasia(84.38％vs 51.92％)and decreased hemoglobin concentration(17.75％vs 5.77％)in the long course group were significantly higher than those in the routine course(all P＜0.05).Conclusion Long-term use of caffeine citrate injection to correct gestational age＞34 weeks has no significant effect on clinical treatment,neurological function and intellectual development of very low birth weight infants.关键词
枸橼酸咖啡因注射液/早产儿/极低出生体质量儿/呼吸暂停/疗程/安全性Key words
caffeine citrate injection/premature baby/very low birth weight infants/apnea/course of treatment/security分类
医药卫生引用本文复制引用
赵燕凤,杨飞,周晓媚,叶林,常晓雯,叶仙丽,王艳..不同疗程枸橼酸咖啡因治疗极低出生体质量儿的临床研究[J].中国临床药理学杂志,2024,40(16):2325-2328,4.
