中国临床药理学杂志2024，Vol.40Issue(16)：2428-2432,5.DOI:10.13699/j.cnki.1001-6821.2024.16.027
赛洛西宾治疗难治性抑郁症机制的研究现状
Research status of mechanism of psilocybin in the treatment of treatment-resistant depression
摘要
Abstract
Refractory depression is a drug-resistant subtype of major depressive disorder for which there is a lack of effective and durable treatments.Seroxibine,the active substance in the mushroom Capsicum annuum,is a natural 5-hydroxytryptamine hallucinogen that activates the 5-hydroxytryptamine 2A receptor to mediate multiple aspects of antidepressant effects.In recent years,it has received renewed attention for its outstanding therapeutic effects in the treatment of refractory depression or other psychiatric disorders.Therefore,this paper summarizes the studies on neuroplasticity,brain neural connectivity network,neurotransmitters,immune factors,microbiota-gut-brain axis,and clinical efficacy of seloxipine in domestic and international literature,and explores the possible mechanisms of seloxipine's effect on refractory depression,with a view to providing theoretical basis for the clinical application of this drug.关键词
赛洛西宾/难治性抑郁症/5-羟色胺2A受体/神经可塑性/信号通路Key words
psilocybin/treatment-refractory depression/5-hydroxytryptamine 2A receptor/neuronal plasticity/signaling pathway分类
医药卫生引用本文复制引用
华广顺,郭晨阳,张航,郭钰婷,龚思淼,杨彦..赛洛西宾治疗难治性抑郁症机制的研究现状[J].中国临床药理学杂志,2024,40(16):2428-2432,5.基金项目
四川省科技计划基金资助项目(2021YFS0041) （2021YFS0041）
四川省中央引导地方科技发展专项基金资助项目(2022ZYD0064) （2022ZYD0064）
