中国临床药理学杂志2024，Vol.40Issue(16)：2433-2437,5.DOI:10.13699/j.cnki.1001-6821.2024.16.028
Hedgehog信号通路在肌少-骨质疏松症中的肌骨共生作用
Role of Hedgehog signaling pathway in muscle bone symbiosis in osteo-sarcopenia
摘要
Abstract
This article elaborates on the complex cross-talk and close relationship between muscles and bones involved in this disease,as well as its pathogenesis.It also summarizes that the difficulty of its treatment lies in the need to simultaneously consider both muscles and bones.And elaborated on the key role of the Hedgehog signaling pathway in embryonic development,tissue morphology establishment,and human tissue regeneration and repair.Investigated the remodeling effect of the Hedgehog signaling pathway on skeletal muscle from three aspects:Proliferation and differentiation of muscle stem cells,precursor cell and muscle fiber generation,inhibition of inflammation,and regulation of immunity;this article elucidates the role of the Hedgehog signaling pathway in bone reconstruction from two aspects.关键词
Hedgehog信号通路/肌少-骨质疏松症/成肌/成骨/作用机制Key words
Hedgehog signaling pathway/muscle deficiency osteoporosis/myoblast/osteogenesis/mechanism of action分类
药学引用本文复制引用
刘晏东,邓强,李中锋,彭冉东,王雨榕,李家明,马平怡,杜健强..Hedgehog信号通路在肌少-骨质疏松症中的肌骨共生作用[J].中国临床药理学杂志,2024,40(16):2433-2437,5.基金项目
甘肃省联合科研基金资助项目(23JRRA1534) （23JRRA1534）
兰州市科技计划基金资助项目(2022-3-30) （2022-3-30）
