中国临床药理学杂志2024，Vol.40Issue(16)：2442-2446,5.DOI:10.13699/j.cnki.1001-6821.2024.16.030
2型糖尿病胰岛β细胞损伤机制的研究现状
Research status of mechanisms of pancreatic islet beta cell injury in type 2 diabetes
摘要
Abstract
The number of type 2 diabetes(T2DM)accounts for more than 90％of all Diabetes mellitus(DM).The decrease of islet β cell mass and dysfunction are the core links of T2DM.With the prolongation of the course of disease,the number and function of β cells are gradually attenuated,and the damage mechanism has not been elucidated.At present,it is believed that it is closely related to metabolic stress,abnormal regulation of insulin secretion,changes in islet microenvironment,mitochondrial damage,glycolipid toxicity and dedifferentiation of islet β cells.Therefore,the mechanism of islet β cell damage in T2DM is summarized and elaborated in order to provide some reference for the precise intervention of T2DM.关键词
2型糖尿病/胰岛β细胞/损伤机制Key words
type 2 diabetes/pancreatic β cells/damage mechanism分类
药学引用本文复制引用
翟艳会,梁永林,安冬,张媛媛,苏菲,关晓文,朱向东..2型糖尿病胰岛β细胞损伤机制的研究现状[J].中国临床药理学杂志,2024,40(16):2442-2446,5.基金项目
甘肃省科技厅教育科技创新基金资助项目(2021CYZC-03) （2021CYZC-03）
宁夏回族自治区重点研发计划基金资助项目(2022BEG02034) （2022BEG02034）
