中国临床药理学杂志2024，Vol.40Issue(16)：2447-2451,5.DOI:10.13699/j.cnki.1001-6821.2024.16.031
艾司氯胺酮与术后认知功能障碍的研究现状
Research status of esketamine and postoperative cognitive dysfunction
摘要
Abstract
Objective As a new type of N-methyl-D-aspartic acid(NMDA)receptor antagonist,esmolamine has the same pharmacological mechanism and site as ketamine,but its affinity to NMDA receptor is 3-4 times that of ketamine,and its analgesic effect is 2-2.5 times that of ketamine.Postoperative cognitive dysfunction is the most common complication in elderly patients undergoing anesthesia and surgery.The incidence is higher in elderly patients over 65 years old,which seriously affects the quality of postoperative recovery and increases the medical burden.It is one of the clinical problems to be solved urgently.In recent years,with the clinical application of esmolamine,it has been found that intraoperative use of esmolamine can make the hemodynamics of surgical patients more stable,reduce the release of inflammatory factors and reduce the incidence of postoperative cognitive impairment.This article reviews the research progress of the effect of esmolamine on postoperative cognitive dysfunction in the field of clinical and basic research at home and abroad,in order to provide clinical reference.关键词
艾司氯胺酮/术后认知功能障碍/围术期神经认知障碍Key words
esmolamine/postoperative cognitive impairment/perioperative neurocognitive impairment分类
医药卫生引用本文复制引用
高世龙,韩学成,马文虎,王学军..艾司氯胺酮与术后认知功能障碍的研究现状[J].中国临床药理学杂志,2024,40(16):2447-2451,5.基金项目
国家自然科学基金面上资助项目(81660197) （81660197）
青海省自然科学基金资助项目(2019-ZJ-930) （2019-ZJ-930）
