摘要
Abstract
AIM To search for additional genetic susceptibility loci for lung cancer,screening potential therapeutic sites.METHODS Summary data from 4 preceding genome-wide association studies conducted in Japan,South Korea,Finland,and the United Kingdom were systematically compiled.Then,quality control procedures were executed utilizing the R software environment(Version 4.1.0).Subsequently,METAL software(Windows)was used to conduct inverse-variance weighted Meta-analysis on the data from East Asian,European,and trans-ethnic populations to identify genome-wide significant loci(P＜5.0×10-8).Subsequent functional annotations for the identified genome-wide significant loci were conducted using the RegulomeDB,3D-SNP,and HaploReg databases.Lung cancer risk genes reaching significant differentiation(P＜2.57×10-6)were discerned by using a gene-based analytical approach.RESULTS A total of 33 novel SNPs were identified at 4 loci(3q28,6p21.32,22q12.1,and 20q13.33),which were found to be significantly associated with lung cancer risk.Additionally,2 new genes,TTC28 and CCDC117 located at 22q12.1,were discovered to be linked with lung cancer susceptibility.CONCLUSION This investigation has successfully identified new genetic variants and genes associated with the risk of lung cancer,providing a new perspective on the genetic mechanisms of lung cancer.关键词
肺癌/基因组关联研究/单核苷酸多态性/易感基因位点Key words
lung cancer/genome-wide association study/single nucleotide polymorphism/susceptibility loci
