复方甘草酸苷片与转移因子胶囊联合卤米松乳膏对白癜风患者皮损复色情况的影响OACSTPCD
Effect of Compound Glycyrrhizin Tablets and Transfer Factor Capsules Combined with Halometasone Cream in Treating Skin Lesion Repigmentation in Patients with Vitiligo
目的:探讨复方甘草酸苷片与转移因子胶囊联合卤米松乳膏对治疗白癜风患者皮损复色情况的临床效果.方法:选取2018年3月-2023年3月笔者医院收治的96例白癜风患者为研究对象,采用便利抽样法随机分成观察组和对照组,各48例,其中对照组采用卤米松乳膏治疗,观察组在对照组基础上采用复方甘草酸苷片与转移因子胶囊进行联合治疗,比较两组患者不良反应情况,于治疗3个月后两组患者美学指标(皮损白斑面积、皮损色素积分、复色率)、疾病相关生化指标[趋化因子10(CXCL10)、趋化因子受体3(CXCR3)、辅助性T细胞17(Th17)、辅助性T细胞22(Th22)],于治疗前及治疗3个月后,比较两组患者免疫功能相关指标[干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)、白细胞介素-17(IL-17)]、抗氧化指标[活性氧(ROS)、超氧化物歧化酶(SOD)、丙二醛(MDA)]、甲状腺功能指标[游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)],于治疗6个月后比较两组患者复发率.结果:治疗3个月后,观察组皮损色素积分、复色率明显高于对照组(P＜0.05);皮损白斑面积、疾病相关生化指标均明显低于对照组(P＜0.05);治疗3个月后,两组患者血清免疫功能相关指标(IFN-γ、IL-17)、抗氧化指标(ROS、MDA)、甲状腺功能指标均较治疗前下降,且观察组明显低于同期对照组(P＜0.05);IL-4、SOD水平均较治疗前上升,且观察组明显高于同期对照组(P＜0.05).治疗后6个月,观察组复发率明显低于对照组(P＜0.05).两组患者均无明显不良反应.结论:复方甘草酸苷片与转移因子胶囊联合卤米松乳膏能够有效调节白癜风患者免疫功能,维持机体氧化应激平衡,从而减轻患者皮损情况,对患者甲状腺功能产生积极影响,安全性较高.
Objective To explore the clinical effect of compound glycyrrhizin tablets and transfer factor capsules combined with halometasone cream in the treatment of skin lesion repigmentation in patients with vitiligo.Methods 96 patients with vitiligo who were cured and treated in the author's hospital from March 2018 to March 2023 were selected as the study subjects and were randomly divided into observation group and control group with 48 cases in each group by convenient sampling method.The control group was treated with halometasone cream,whereas the observation group was given combined therapy with compound glycyrrhizin tablets and transfer factor capsules on the basis of the control group.The adverse reactions,aesthetic indicators(skin lesion white spot area,skin lesion pigment score,repigmentation rate)and disease-related biochemical indicators[chemokine ligand 10(CXCL10),chemokine receptor 3(CXCR3),helper T cell 17(Th17),helper T cell 22(Th22)]after 3 months of treatment,immune function-related indicators[interferon-γ(IFN-γ),interleukin-4(IL-4),interleukin-17(IL-17)],antioxidant indicators[reactive oxygen species(ROS),superoxide dismutase(SOD),malondialdehyde(MDA)]and thyroid function indicators[free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH)]before treatment and after 3 months of treatment and recurrence rate after 6 months of treatment were compared between the two groups of patients.Results After 3 months of treatment,the skin pigment score and repigmentation rate in observation group was significantly higher compared with that in control group(P＜0.05)while the skin lesion white spot area and disease-related biochemical indicators were significantly lower than those in control group(P＜0.05).The levels of serum immune function-related indicators(IFN-γ,IL-17),antioxidant indicators(ROS,MDA)and thyroid function indicators in the two groups were declined after 3 months of treatment than those before treatment,and the above levels in observation group were significantly lower(P＜0.05).The levels of IL-4 and SOD were risen compared with those before treatment,and the observation group had significantly higher levels(P＜0.05).The recurrence rate in observation group at 6 months after treatment was significantly lower compared to control group(P＜0.05).There were no obvious adverse reactions in both groups of patients.Conclusion Compound glycyrrhizin tablets and transfer factor capsules combined with halometasone cream can effectively regulate the immune function and maintain the body's oxidative stress balance in patients with vitiligo,thereby relieving the skin lesions and it has a positive impact on thyroid function of patients with high safety.
李飞;何荣
四川省内江市东兴区人民医院皮肤科 四川 内江 641000
临床医学
复方甘草酸苷片转移因子胶囊卤米松乳膏白癜风
compound glycyrrhizin tabletstransfer factor capsuleshalometasone creamvitiligo
《中国美容医学》 2024 (009)
105-109 / 5
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