摘要
Abstract
Objective To analyze the cosmetic effect of 420 nm intense pulsed light(IPL)and ablative fractional laser(AFL)in the treatment of severe acne scars.Methods A total of 107 patients with severe acne scars admitted to the hospital from February 2023 to August 2023 were selected as study subjects and divided into the IPL group(n=35),the AFL group(n=35),and the combined group(n=37)according to the random number table method.The IPL group was treated with 420 nm IPL,the AFL group received ablative fractional CO2 laser treatment,and the combined group received 420 nm IPL combined with fractional CO2 laser treatment.After three courses of treatment,the efficacy,erythema,pigmentation,scar quality of life,skin barrier,and occurrence of adverse reactions were compared.Results The effective rate in the combined group was significantly higher than that in the IPL group and the AFL group(P＜0.05),but there was no statistical significance between the IPL group and the AFL group(P＞0.05).After treatment,the Echelle d'Evaluation Clinique des Cicatrices d'acné(ECCA)score was as follows:combined group＜AFL group＜IPL group.The effective treatment rates for erythema and pigmentation in the combined group were significantly higher than those in the AFL group and the IPL group(P＜0.05),but there were no statistical differences between the AFL group and the IPL group(P＞0.05).After treatment,the Dermatology Life Quality Index(DLQI)score was lower in the combined group than in the IPL group and the AFL group(P＜0.05),but the difference in DLQI score between the IPL group and the AFL group was not statistically significant(P＞0.05).After treatment,the skin water content decreased while the transepidermal water loss(TEWL)increased in the three groups compared to before treatment,but there were no statistical differences among the three groups(P＞0.05).At 2 months after the last treatment,the skin water content in all three groups was enhanced while the TEWL was reduced compared to before treatment.The skin water content in the combined group was higher than that in the IPL group and the AFL group,while the TEWL was lower than that in the IPL group and the AFL group(P＜0.05),but there were no statistical differences between the IPL group and the AFL group(P＞0.05).During treatment,there were no statistical differences in adverse reactions such as tingling and flushing among the three groups(P＞0.05).Conclusion Both 420 nm IPL and fractional CO2 laser have significant efficacy in the treatment of severe acne scars,but the combined treatment has better efficacy.It can better improve erythema,pigmentation,and scar status,enhance dermatology-related quality of life,and improve skin barrier function.Its safety is worthy of affirmation.关键词
痤疮/瘢痕/420nm强脉冲光/剥脱性点阵激光/美学效果Key words
acne/scars/420 nm intense pulsed light/ablative fractional laser/cosmetic effect分类
医药卫生
