中国免疫学杂志2024，Vol.40Issue(8)：1569-1578,10.DOI:10.3969/j.issn.1000-484X.2024.08.001
解析疫苗接种后抗体记忆的维持:进展与挑战
Investigating the duration of antibody response in vaccination:Current progresses and challenges
李嘉杰 1汪舒杨 2王思捷 3马思轩 3冀正林 2刘万里2
作者信息
- 1. 清华大学生命科学学院,免疫学研究所,生命中心,北京 100084||清华大学致理书院,北京 100084
- 2. 清华大学生命科学学院,免疫学研究所,生命中心,北京 100084
- 3. 中国农业大学生物学院,北京 100193
- 折叠
摘要
Abstract
In the earliest days,the idea that surviving a single infection often resulted in lifelong immunity to the infecting pathogen was recorded and then led to the discovery of vaccination.We have now confirmed that such protection is primarily based on the generation of immunological memory in antibody response.With the wide implementation of more and more vaccines around the world,it is well documented that different vaccines have different potential regarding to the duration of antibody response.In clinical observations,live-attenuated vaccines often elicit long-term immunity but are also accompanied with risks in safety that are hard to avoid.In order to develop novel vaccines with both excellent potential in eliciting antibody memory and low safety risk,it is critical to further investigate the mechanism of antibody memory in the perspective of immunology.Antibody memory is mediated by certain long-lived B cells:long-lived plasma cell can secret antibody to maintain serum antibody titer while memory B cell contributes to the rapid immune response during the secondary encounter of pathogens.Cellular and molecular processes that drive the production of long-lived plasma cells and memory B cells are subjects of intensive research and have important implications for global health.Several factors in the vaccine would indeed affect and regulate these processes,including the antigen valency,vaccine kinetics and the signal integration of both antigen and danger molecules.Many studies have focused on strategies to manipulate these factors to improve or develop new vaccines.Here,we will summarize our current knowledge on how the component in vaccines will affect their potential in generating and sustaining antibody memory,and also point out the challenges we face in the route of developing a"perfect"vaccine.关键词
减毒活疫苗/中和抗体/B细胞/抗体记忆Key words
Live-attenuated vaccine/Neutralizing antibody/B cell/Antibody memory分类
医药卫生引用本文复制引用
李嘉杰,汪舒杨,王思捷,马思轩,冀正林,刘万里..解析疫苗接种后抗体记忆的维持:进展与挑战[J].中国免疫学杂志,2024,40(8):1569-1578,10.
