中国免疫学杂志2024，Vol.40Issue(8)：1584-1589,6.DOI:10.3969/j.issn.1000-484X.2024.08.003
活动性梅毒患者梅毒血清特异性抗体水平与体内免疫球蛋白水平的相关性研究
Study on correlation between treponema pallidum specific antibodies levels of syphilis and immunoglobulin levels in active syphilis patients
摘要
Abstract
Objective:To investigate the correlation between the level of treponema pallidum specific antibodies(TPAb)and immunoglobulin A/E/M/G(IgA/E/M/G)and IgG subtypes in active syphilis patients,so as to provide a basis for the comprehensive di-agnosis and treatment and prognosis evaluation of clinical syphilis.Methods:Active syphilis patients admitted to the First Affiliated Hospital of Soochow University in 2023 were divided into 1∶4+and 1∶16+groups according to the syphilis toluidine red unheated se-rum test(TRUST),and healthy control group were selected for the detection of TPAb by chemiluminescence microparticle immunoas-say(CMIA).The contents of IgA/E/M/G and IgG1/2/3/4 were determined by immunoturbidimetry.Results:A total of 206 patients with active syphilis(125 males and 81 females)aged(46.05±19.58)years were included in this study.Compared with the healthy control group,IgG2 was decreased and TPAb,IgA/E/M/G and IgG1/3/4 levels were increased in the active syphilis group,with statistically significant differences in TPAb,IgE and IgG1/2/3 levels(P<0.05).Compared with the healthy control group,TRUST 1∶4+group had statistical differences in TPAb,IgE and IgG2,and TPAb was significantly correlated with IgE and IgG2/4.The levels of TPAb,IgA/E/M/G and IgG1/2/3 in TRUST 1∶16+group were statistically significant,and TPAb was significantly correlated with IgE and IgG4(P<0.05).In addition,there were significant differences in TPAb,IgG and IgG1/3 between the two positive groups(P<0.05).Conclu-sion:The levels of TPAb and Ig in active syphilis patients with different TRUST titers are significantly different.TPAb combined with Ig can be used to monitor the strength of syphilis activity,IgA/M/G and IgG1/3 may be candidate biomarkers.关键词
活动性梅毒/梅毒血清特异性抗体(TPAb)/免疫球蛋白/IgG亚型/相关性分析Key words
Active syphilis/Treponema pallidum specific antibodies(TPAb)/Immunoglobulin/IgG subtype/Correlation analysis分类
医药卫生引用本文复制引用
王瑶,丁洁,杨倩,施银娟,梁玉婷,何杨,张胜..活动性梅毒患者梅毒血清特异性抗体水平与体内免疫球蛋白水平的相关性研究[J].中国免疫学杂志,2024,40(8):1584-1589,6.基金项目
国家自然科学基金(82070123). （82070123）
